Induction of Stat3, a Signal Transducer and Transcription Factor, in Reactive Microglia following Transient Focal Cerebral Ischaemia
Explore this paper's citation graph
Summary
Results suggest that Stat3 mediates signal transduction and activates transcription in reactive microglia in vivo following brain ischaemia.
- Type
- article
- Published
- 1996-12-01
- Cited by
- 113
- References
- 49
- Access
- Open access
- OpenAlex
- https://openalex.org/W8996811
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26784354
Keywords
Geology
References
- Demonstration of poly-N-acetyl lactosamine residues in ameboid and ramified microglial cells in rat brain by tomato lectin binding.
- Cytokines, inflammation, and brain injury: role of tumor necrosis factor-alpha.
- Epidermal growth factor and lipopolysaccharide activate Stat3 transcription factor in mouse liver.
- Activation of JAK kinases and STAT proteins by interleukin‐2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes.
- A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin‐6.
- Transcriptional activation of the IL-6 response element in the junB promoter is mediated by multiple Stat family proteins.
- Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6.
- Requirement of serine phosphorylation for formation of STAT-promoter complexes.
- Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease
- Cytokines in cerebral ischemia: Expression of transforming growth factor beta-1 (TGF-β1) mRNA in the postischemic adult rat hippocampus
- Interleukin‐2 induces tyrosine phosphorylation and nuclear translocation of stat3 in human T lymphocytes
- Cerebral hypoxia-ischemia stimulates cytokine gene expression in perinatal rats.
- Early 72-kDa heat shock protein induction in microglial cells following focal ischemia in the rat brain.
- Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation.
- Microglia: Immune Network in the CNS
- Penumbral Tissues Salvaged by Reperfusion Following Middle Cerebral Artery Occlusion in Rats
- Activation of Acute Phase Response Factor (APRF)/Stat3 Transcription Factor by Growth Hormone (*)
- Apoptosis and c‐Jun in the thalamus of the rat following cortical infarction
- Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.
- Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors
Cited by
- Glial activation in the immature rat brain: implication of inflammatory transcription factors and cytokine expression.
- Role of the JAK/STAT Signal Transduction Pathway in the Regulation of Gene Expression in CNS
- IGFBP2 POTENTIATES EGFR-STAT3 SIGNALING IN GLIOMA
- STAT3 signaling after traumatic brain injury
- Ciliary Neurotrophic Factor and Stress Stimuli Activate the Jak-STAT Pathway in Retinal Neurons and Glia
- 2-Arachidonylglycerol Protects Primary Astrocytes Exposed to Oxygen-Glucose Deprivation Through a Blockade of NDRG2 Signaling and STAT3 Phosphorylation
- Therapeutic Potential of PPARγ Activation in Stroke
- Necdin is a novel modulator in microglia proliferation in the murine brain following cerebral ischemia
- Glial Reactivity in Ciliary Neurotrophic Factor-Deficient Mice after Optic Nerve Lesion
- Expression and activation of STAT3 in ischemia-induced retinopathy.
- The Effects of Fludarabine on Rat Cerebral Ischemia
- Sequential expression of surface antigens and transcription factor NFkappaB by hippocampal cells in excitotoxicity and experimental epilepsy.
- ALTERED GABAA RECEPTOR EXPRESSION DURING EPILEPTOGENESIS
- Neuroprotective Effect of Recombinant Human Granulocyte Colony-Stimulating Factor in Transient Focal Ischemia of Mice
- Detection of protein biomarkers using high-throughput immunoblotting following focal ischemic or penetrating ballistic-like brain injuries in rats
- Ischemic preconditioning-induced expression of gp130 and STAT3 in astrocytes of the rat hippocampus.
- STAT signalling in the mature and aging brain
- The phosphorylation of STAT6 during ischemic reperfusion in rat cerebral cortex
- Phosphorylation of signal transducer and activator of transcription-3 (Stat3) after focal cerebral ischemia in rats.
- Expression and Activation of STAT3 in the Astrocytes of Optic Nerve in a Rat Model of Transient Intraocular Hypertension
Related papers
No related papers recorded.