Amorfrutin A inhibits TNF-α-induced NF-κB activation and NF-κB-regulated target gene products.
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Summary
Results suggest that amorfrutin A potentiates TNF-α-induced apoptosis, and could be a valuable candidate for the intervention of NF-κB-dependent pathological conditions such as inflammation.
- Type
- article
- Published
- 2014-07-01
- Cited by
- 29
- References
- 33
- OpenAlex
- https://openalex.org/W2070597393
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4446071
Keywords
NF-κB, IκBα, Inflammation, Tumor necrosis factor alpha, NFKB1
References
- Nuclear factor-κB: The enemy within
- Naturally improving insulin resistance with amorfrutins
- Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
- Amorfrutins are potent antidiabetic dietary natural products
- Inhibiting NF-κB Activation by Small Molecules As a Therapeutic Strategy
- Missing pieces in the NF-kappaB puzzle.
- Structural characterization of amorfrutins bound to the peroxisome proliferator-activated receptor γ.
- NF-κB: linking inflammation and immunity to cancer development and progression
- IKK-β links inflammation to obesity-induced insulin resistance
- The 65-kDa subunit of human NF-kappa B functions as a potent transcriptional activator and a target for v-Rel-mediated repression.
- The Crystal Structure of the IκBα/NF-κB Complex Reveals Mechanisms of NF-κB Inactivation
- The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation.
- Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity.
- Regulation of NF-κB by Ubiquitination
- TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways.
- An Atypical E3 Ligase Zinc Finger Protein 91 Stabilizes and Activates NF-κB-inducing Kinase via Lys63-linked Ubiquitination*
- Regulation of NF-κB in Autoimmunity
- NF-κB functions as a tumour promoter in inflammation-associated cancer
- Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression.
- Tumour necrosis factor and cancer
Cited by
- Blockade of TNF-α-induced NF-κB signaling pathway and anti-cancer therapeutic response of dihydrotanshinone I.
- Isolation and purification of prenylated phenolics from Amorpha fruticosa by high-speed counter-current chromatography.
- Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria.
- Amorfrutins Are Natural PPARγ Agonists with Potent Anti-inflammatory Properties.
- Berberine improves airway inflammation and inhibits NF-κB signaling pathway in an ovalbumin-induced rat model of asthma
- Ataxia-telangiectasia mutated activation mediates tumor necrosis factor-alpha induced MMP-13 up-regulation and metastasis in lung cancer cells
- Baicalein inhibits TNF-α-induced NF-κB activation and expression of NF-κB-regulated target gene products.
- Food-Derived Natural Compounds for Pain Relief in Neuropathic Pain
- Analysis of bioactive constituents from the leaves of Amorpha fruticosa L
- Antibacterial and cytotoxic phenolic metabolites from the fruits of Amorpha fruticosa
- Amorpha fruticosa – A Noxious Invasive Alien Plant in Europe or a Medicinal Plant against Metabolic Disease?
- Anti-inflammatory and anti-oxidative activities of daidzein and its sulfonic acid ester derivatives
- Amorfrutin A inhibits TNF-α induced JAK/STAT signaling, cell survival and proliferation of human cancer cells
- Sulphur dioxide suppresses inflammatory response by sulphenylating NF-κB p65 at Cys38 in a rat model of acute lung injury.
- CDCA3 promotes cell proliferation by activating the NF-κB/cyclin D1 signaling pathway in colorectal cancer.
- Copper and arsenic‐induced oxidative stress and immune imbalance are associated with activation of heat shock proteins in chicken intestines
- Raging the War Against Inflammation With Natural Products
- Lobaric acid and pseudodepsidones inhibit NF-κB signaling pathway by activation of PPAR-γ.
- Dihydroberberine, a hydrogenated derivative of berberine firstly identified in Phellodendri Chinese Cortex, exerts anti-inflammatory effect via dual modulation of NF-κB and MAPK signaling pathways.
- Involvement of the NF-κB signaling pathway in proliferation and invasion inhibited by Zwint-1 deficiency in Pancreatic Cancer Cells
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