Heterologous protection against influenza by injection of DNA encoding a viral protein.
Explore this paper's citation graph
Summary
To generate a viral antigen for presentation to the immune system without the limitations of direct peptide delivery or viral vectors, plasmid DNA encoding influenza A nucleop protein was injected into the quadriceps of BALB/c mice and resulted in the generation of nucleoprotein-specific CTLs.
- Type
- article
- Published
- 1993-03-19
- Cited by
- 2,476
- References
- 50
- OpenAlex
- https://openalex.org/W2070426326
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10336675
Keywords
Nucleoprotein, Virology, Heterologous, Cytotoxic T cell, Biology
References
- Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells
- Role of the major histocompatibility complex class I antigens in tumor growth and metastasis.
- Recombinant vaccinia viruses as vectors for studying T lymphocyte specificity and function.
- Immunogenicity of a Haemophilus influenzae polysaccharide-Neisseria meningitidis outer membrane protein complex conjugate vaccine.
- Influenza nucleoprotein-specific cytotoxic T-cell clones are protective in vivo.
- Expression of the Epstein-Barr virus gp350/220 gene in rodent and primate cells
- Evolution of influenza A virus nucleoprotein genes: implications for the origins of H1N1 human and classical swine viruses
- Inhibition of multicycle influenza virus replication by hybrid antibody-directed cytotoxic T lymphocyte lysis.
- Saponin adjuvant induction of ovalbumin-specific CD8+ cytotoxic T lymphocyte responses.
- Induction of a cellular immune response to a foreign antigen by a recombinant Listeria monocytogenes vaccine.
- Processing of exogenous liposome-encapsulated antigens in vivo generates class I MHC-restricted T cell responses.
- Disseminated vaccinia in a military recruit with human immunodeficiency virus (HIV) disease.
- Transfer of specific cytotoxic T lymphocytes protects mice inoculated with influenza virus
- Biological properties of an influenza A virus-specific killer T cell clone. Inhibition of virus replication in vivo and induction of delayed- type hypersensitivity reactions
- Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle.
- Humoral and cell-mediated immune responses to live recombinant BCG–HIV vaccines
- Brefeldin A specifically inhibits presentation of protein antigens to cytotoxic T lymphocytes.
- In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine
- Influenza A virus nucleoprotein is a major target antigen for cross-reactive anti-influenza A virus cytotoxic T lymphocytes.
- Antigen recognition by class I-restricted T lymphocytes.
Cited by
- The Effect of CTAB Concentration in Cationic PLG Microparticles on DNA Adsorption and in Vivo Performance
- Development of DNA Vaccination Approach for Tumor Immunotargeting
- Vaccination of mice with MUC1 cDNA suppresses the development of lung metastases
- Estimation of the effective doses of nasal-inactivated influenza vaccine in humans from mouse-model experiments.
- Adjuvant-Specific Serum Cytokine Profiles in the Context of a DNA Prime-Protein Boost HIV-1 Vaccine: A Dissertation
- Delivery of protein antigen to the major histocompatibility complex class I-restricted antigen presentation pathway.
- Cytokine gene expression in epidermis with biological effects following injection of naked DNA
- Bacterial Lipopolysaccharide Copurifies with Plasmid DNA: Implications for Animal Models and Human Gene Therapy
- DNA vector constructs that prime hepatitis B surface antigen-specific cytotoxic T lymphocyte and antibody responses in mice after intramuscular injection.
- In vivo induction of cytotoxic T lymphocytes specific for a single epitope introduced into an unrelated molecule.
- Serum and colostrum antibody responses induced by jet-injection of sheep with DNA encoding a Cryptosporidium parvum antigen.
- Genetic Immunization
- DNA immunization confers protective immunity on mice challenged intravaginally with herpes simplex virus type 2.
- DNA vaccination using expression vectors carrying FIV structural genes induces immune response against feline immunodeficiency virus.
- Immunity to Plasmodium falciparum malaria sporozoites by somatic transgene immunization
- Intradermal immunization with a bovine herpesvirus-1 DNA vaccine induces protective immunity in cattle.
- Immunoglobulin G subclass responses in mice immunized with plasmid DNA encoding the CFA/I fimbria of enterotoxigenic Escherichia coli.
- A novel immunization method to induce cytotoxic T-lymphocyte responses (CTL) against plasmid-encoded herpes simplex virus type-1 glycoprotein D.
- Enhanced cellular immunity to hepatitis C virus nonstructural proteins by codelivery of granulocyte macrophage-colony stimulating factor gene in intramuscular DNA immunization.
- Potency of an experimental DNA vaccine against Aujeszky's disease in pigs.
Related papers
- Purified influenza virus nucleoprotein protects mice from lethal infection.
- Strategies for inducing protection against avian influenza A virus subtypes with DNA vaccines.
- Live attenuated influenza virus vaccines. Strains with temperature-sensitive defects in P3 protein and nucleoprotein.
- Influenza nucleoprotein-specific cytotoxic T-cell clones are protective in vivo.
- Homotypic and heterotypic protection against influenza virus infection in mice by recombinant vaccinia virus expressing the haemagglutinin or nucleoprotein of influenza virus.
- Assessment of the extent of variation in influenza A virus cytotoxic T-lymphocyte epitopes by using virus-specific CD8+ T-cell clones.
- 2009 pandemic H1N1 influenza virus replicates in human lung tissues
- Failure of attenuated temperature-sensitive influenza A (H3N2) virus to induce heterologous interference in humans to parainfluenza type 1 virus
- Detection of Nonhemagglutinating Influenza A(H3) Viruses by Enzyme-Linked Immunosorbent Assay in Quantitative Influenza Virus Culture
- Biological properties of an influenza A virus-specific killer T cell clone. Inhibition of virus replication in vivo and induction of delayed- type hypersensitivity reactions