The Origin and Pathogenesis of Epithelial Ovarian Cancer- a Proposed Unifying Theory
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Summary
It has been proposed that serous tumors arise from the implantation of epithelium (benign or malignant) from the fallopian tube and preliminary data suggest that mucinous and transitional (Brenner) tumors arose from transitional-type epithelial nests at the tubal-mesothelial junction by a process of metaplasia.
- Type
- article
- Published
- 2010-03-01
- Cited by
- 1,871
- References
- 45
- Access
- Open access
- OpenAlex
- https://openalex.org/W2070369494
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33753425
Keywords
Serous fluid, Carcinosarcoma, Ovarian cancer, Serous carcinoma, Pathology
References
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- Mutation of K-ras protooncogene in human ovarian epithelial tumors of borderline malignancy.
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- Results From Four Rounds of Ovarian Cancer Screening in a Randomized Trial
- Ovarian dysplasia in prophylactic oophorectomy specimens
- Candidate serous cancer precursors in fallopian tube epithelium of BRCA1/2 mutation carriers
- The Fallopian Tube: Primary Site of Most Pelvic High-grade Serous Carcinomas
- Metastatic patterns at autopsy in patients with ovarian carcinoma
- Cystic and Adenofibromatous Clear Cell Carcinomas of the Ovary: Distinctive Tumors That Differ in Their Pathogenesis and Behavior: A Clinicopathologic Analysis of 122 Cases
- Minimal uterine serous carcinoma: diagnosis and clinicopathologic correlation.
- Ovarian Conservation at the Time of Hysterectomy and Long-Term Health Outcomes in the Nurses’ Health Study
- The Tubal Fimbria Is a Preferred Site for Early Adenocarcinoma in Women With Familial Ovarian Cancer Syndrome
- The Development of High-grade Serous Carcinoma From Atypical Proliferative (Borderline) Serous Tumors and Low-grade Micropapillary Serous Carcinoma: A Morphologic and Molecular Genetic Analysis
- Atypical Epithelial Proliferation in Fallopian Tubes in Prophylactic Salpingo-oophorectomy Specimens from BRCA1 and BRCA2 Germline Mutation Carriers
- Analysis of DNA Copy Number Alterations in Ovarian Serous Tumors Identifies New Molecular Genetic Changes in Low-grade and High-grade Carcinomas
- Histopathologic features of ovaries at increased risk for carcinoma. A case-control analysis.
- Molecular genetics for the clinician
- Serous Carcinogenesis in the Fallopian Tube: A Descriptive Classification
- Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract
- Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer
Cited by
- Gene methylation profiles as prognostic markers in ovarian clear cell and endometrioid adenocarcinomas.
- Modeling high-grade serous ovarian carcinogenesis from the fallopian tube
- Vorläuferläsionen der Ovarialkarzinome
- Frequency of Serous Tubal Intraepithelial Carcinoma in Various Gynecologic Malignancies: A Study of 300 Consecutive Cases
- Enhanced efficacy and specificity of epithelial ovarian carcinogenesis by embedding a DMBA-coated cloth strip in the ovary of rat
- Fertility and borderline ovarian tumor: a systematic review of conservative management, risk of recurrence and alternative options.
- Apolipoprotein Concentrations Are Elevated in Malignant Ovarian Cyst Fluids Suggesting That Lipoprotein Metabolism Is Dysregulated in Epithelial Ovarian Cancer
- SOX2 Expression and Prognostic Significance in Ovarian Carcinoma
- Differential expression of IL-8 and IL-8 receptors in benign, borderline and malignant ovarian epithelial tumours.
- New perspectives in ovarian cancer treatment.
- Sohlh2 inhibits ovarian cancer cell proliferation by upregulation of p21 and downregulation of cyclin D1.
- Reactivity of CA19-9 and CA125 in histological subtypes of epithelial ovarian tumors and ovarian endometriosis.
- Preoperative Neutrophil-to-Lymphocyte Ratio as a Predictive and Prognostic Factor for High-Grade Serous Ovarian Cancer
- DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-grade Serous Ovarian Cancer
- Galectin-3 supports stemness in ovarian cancer stem cells by activation of the Notch1 intracellular domain
- Expression of hypothalamic-pituitary-gonadal axis-related hormone receptors in low-grade serous ovarian cancer (LGSC)
- Claudin-4 Expression is Associated With Survival in Ovarian Cancer But Not With Chemotherapy Response
- Genetic epidemiology of ovarian cancer in the 22 Arab countries: A systematic review.
- Hysterectomy and opportunistic salpingectomy (HOPPSA): study protocol for a register-based randomized controlled trial
- Proteases and their inhibitors as prognostic factors for high-grade serous ovarian cancer.
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