Inositol 1,2-cyclic 4,5-trisphosphate concentration relative to inositol 1,4,5-trisphosphate in pancreatic minilobules on stimulation with carbamylcholine in the absence of lithium. Possible role as a second messenger in long- but not short-term responses.
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Summary
Mouse pancreatic minilobules were preincubated with [3H]inositol for 1 h in the absence of lithium, washed, and incubated without and with carbamylcholine without lithium for various times, and I(1,4,5)P3 peaked at 10 s, followed by a fall to a steady-state level which was two-thirds the peak value which was maintained for 20 min.
- Type
- article
- Published
- 1987-10-15
- Cited by
- 32
- References
- 0
- Access
- Open access
- OpenAlex
- https://openalex.org/W1603406891
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10433417
Keywords
Inositol, Stimulation, Lithium (medication), Inositol trisphosphate, Inositol phosphate
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