Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy.
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Summary
It should soon prove possible to block polyamine biosynthesis at every step in the pathway, and this approach will enable a full examination of the potential of this approach.
- Type
- article
- Published
- 1988-02-15
- Cited by
- 1,586
- References
- 133
- OpenAlex
- https://openalex.org/W2161356660
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7727044
Keywords
Polyamine, Carcinogenesis, Cancer research, Biochemistry, In vitro
References
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- A mouse lymphoma cell mutant whose major protein product is ornithine decarboxylase.
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- Increased content of mRNA for a precursor of S-adenosylmethionine decarboxylase in rat prostate after treatment with 2-difluoromethylornithine.
- Inhibition of translation of mRNAs for ornithine decarboxylase and S-adenosylmethionine decarboxylase by polyamines.
- Inhibition of growth of human or hamster pancreatic cancer cell lines by alpha-difluoromethylornithine alone and combined with cis-diamminedichloroplatinum(II).
- Effects of alpha-difluoromethylornithine alone and combined with adriamycin or vindesine on L1210 leukemia in mice, EMT6 solid tumors in mice, and solid tumors induced by injection of hepatoma tissue culture cells in rats.
Cited by
- ASSESSING THE ROLE OF DIETARY POLYAMINES ON THE CONTINUUM OF COLORECTAL CARCINOMA
- Assessing cell proliferation: a methodological review.
- Ornithine Decarboxylase Levels in Patients with Normal Colonic Mucosa
- Human prostatic carcinoma cell lines display altered regulation of polyamine transport in response to polyamine analogs and inhibitors
- Inhibition of cell growth in CaCO2 cells by the polyamine analogue N1,N12‐bis(ethyl)spermine is preceded by a reduction in MYC oncoprotein levels
- Point mutations of ornithine decarboxylase gene are an infrequent event in colorectal cancer but a missense mutation was found in a replication error positive patient with hMSH2 germline mutation.
- Urine polyamines determination using dansyl chloride derivatization in solid-phase extraction cartridges and HPLC.
- Ca2+-RhoA signaling pathway required for polyamine-dependent intestinal epithelial cell migration.
- Regulation of L-arginine transport and metabolism in vascular smooth muscle cells
- Analysis of polyamines as markers of (patho)physiological conditions.
- Cell kinetics and polyamine enzymes in the intestinal mucosa of rats with azoxymethane induced tumours.
- Reversible Regulation of the Transformed Phenotype of Ornithine Decarboxylase- and Ras-Overexpressing Cells by Dominant-Negative Mutants of c-Jun
- Interaction between Polyamines and the Mitogen-Activated Protein Kinase Pathway in the Regulation of Cell Cycle Variables in Breast Cancer Cells.
- Immunomodulation of polyamine biosynthesis in tobacco plants has a significant impact on polyamine levels and generates a dwarf phenotype.
- Effect of polyamines and synthetic polyamine-analogues on the expression of antizyme (AtoC) and its regulatory genes
- Molecular markers for predicting prognosis of renal cell carcinoma.
- Thermospermine is required for stem elongation in Arabidopsis thaliana.
- Entamoeba histolytica, heterologous expression and in situ immunolocalization of ornithine decarboxylase (EhODC).
- Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: sensitization by the MDL 72527 lysosomotropic compound.
- Diamine oxidase-gold ultrastructural localization of histamine in human skin biopsies containing mast cells stimulated to degranulate in vivo by exposure to recombinant human stem cell factor.
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