Sodium fluoride provokes gonadotrope desensitization to gonadotropin-releasing hormone (GnRH) and gonadotrope sensitization to A23187: evidence for multiple G proteins in GnRH action.
Explore this paper's citation graph
Summary
It is suggested that G protein activation by NaF provokes gonadotrope desensitization to GnRH stimulation by both decreasing receptor numbers and by uncoupling of the receptors from inositol phosphate production.
- Type
- article
- Published
- 1992-05-01
- Cited by
- 23
- References
- 35
- OpenAlex
- https://openalex.org/W2056399252
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:532402
Keywords
Gonadotropic cell, Endocrinology, Internal medicine, Gonadotropin-releasing hormone, Phorbol
References
- Stimulation of luteinizing hormone release by sodium fluoride is independent of protein kinase-C activity and unaffected by desensitization to gonadotropin-releasing hormone.
- The gonadotropin-releasing hormone pituitary receptor interacts with a guanosine triphosphate-binding protein: differential effects of guanyl nucleotides on agonist and antagonist binding.
- Stimulation of luteinizing hormone (LH) release and phospholipid breakdown by guanosine triphosphate in permeabilized pituitary gonadotropes: antagonist action suggests association of a G protein and gonadotropin-releasing hormone receptor.
- Mechanisms of hormone receptor-effector coupling: the beta-adrenergic receptor and adenylate cyclase.
- Guanine nucleotides stimulate polyphosphoinositide phosphodiesterase and exocytotic secretion from HL60 cells permeabilized with streptolysin O.
- Differential sensitivity of agonist- and antagonist-occupied gonadotropin-releasing hormone receptors to protein kinase C activators. A marker for receptor activation.
- Guanine nucleotides induce Ca2+-independent insulin secretion from permeabilized RINm5F cells.
- Regulation of thyrotropin-releasing hormone binding by monovalent cations and guanyl nucleotides.
- Fluoride is not an activator of the smaller (20-25 kDa) GTP-binding proteins.
- Phorbol esters reduce gonadotrope responsiveness to protein kinase C activators but not to Ca2+-mobilizing secretagogues. Does protein kinase C mediate gonadotropin-releasing hormone action?
- Regulation of thyrotropin-releasing hormone receptor binding and phospholipase C activation by a single GTP-binding protein.
- Double-antibody method and the protein-A-bearing Staphylococcus aureus cells method compared for separating bound and free antigen in radioimmunoassay.
- THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.
- GnRH-mediated desensitization of the pituitary gonadotrope is not calcium dependent.
- Gonadotropin-releasing hormone action in cultured pituicytes: independence of luteinizing hormone release and adenosine 3',5'-monophosphate production.
- The relationship between gonadotropin-releasing hormone-stimulated luteinizing hormone release and inositol phosphate production: studies with calcium antagonists and protein kinase C activators.
- Coincidence of down-regulation and desensitization in pituitary gonadotrophs stimulated by gonadotropin releasing hormone.
- Agents that decrease gonadotropin-releasing hormone (GnRH) receptor internalization do not inhibit GnRH-mediated gonadotrope desensitization.
- Guanine nucleotides modulate TRH-receptor binding in sheep anterior pituitary.
- Desensitization of cultured pituitary cells to gonadotropin-releasing hormone: evidence for a post-receptor mechanism.
Cited by
- Gonadotropin-Releasing Hormone Receptor Concentration Differentially Regulates Intracellular Signaling Pathways in GGH3 Cells
- Molecular and cellular bases of gonadotropin-releasing hormone action in the pituitary and central nervous system.
- Mechanisms mediating multiple physiological responses to gonadotropin-releasing hormone.
- Regulation of RGS3 and RGS10 palmitoylation by GnRH.
- Development of gonadotrope desensitization to gonadotropin-releasing hormone (GnRH) and recovery are not coupled to inositol phosphate production or GnRH receptor number.
- Addition of catfish gonadotropin-releasing hormone (GnRH) receptor intracellular carboxyl-terminal tail to rat GnRH receptor alters receptor expression and regulation.
- Translational regulation of the gonadotropin-releasing hormone receptor in alpha T3-1 cells.
- Modulation of gonadotropin levels by peptides acting at the anterior pituitary gland.
- Redistribution of Gq/11α in the Pituitary Gonadotrope in Response to a Gonadotropin-Releasing Hormone Agonist.
- Identification by polymerase chain reaction of the G protein-coupled receptor kinases expressed in the mouse gonadotropic alpha T3-1 cell line.
- Investigating crosstalk in lipid rafts between the glucocorticoid receptor and gonadotropin-releasing hormone receptor signaling pathways in a gonadotrope cell line
- Gonadotropin-releasing hormone receptor couples to multiple G proteins in rat gonadotrophs and in GGH3 cells: evidence from palmitoylation and overexpression of G proteins.
- Gonadotropin-releasing hormone increases CD4 T-lymphocyte numbers in an animal model of immunodeficiency.
- The expression, regulation and signal transduction pathways of the mammalian gonadotropin-releasing hormone receptor.
- Gonadotropin-releasing hormone and its analogs.
- In vitro basal and GnRH-stimulated secretion of gonadotrophins reflects long-lasting modulatory effects, and peripheral levels are not predicted by pituitary responsiveness to GnRH.
- Geschlechtsspezifische GnRH-Responsivität und synaptische Plastizität im Hippocampus
- The glucocorticoid receptor plays a central role in mammalian reproduction and signal integration in pituitary gonadotropes
- Post-translational control of luteinizing hormone secretion
- CHAPTER 31 – Gonadotropin-Releasing Hormone Regulation of Gonadotropin Biosynthesis and Secretion
Related papers
- Phosphorothioate analogues of inositol phosphates
- Separation of multiple isomers of inositol phosphates formed in GH3 cells.
- Isolation and separation of inositol 1-phosphate, cyclic inositol 1,2-phosphate, and glycerylphosphoinositol from tissue culture cells labeled with [3H]inositol.
- Stretch increases inositol trisphosphate and inositol tetrakisphosphate in cultured pulmonary vascular smooth muscle cells.
- Noradrenaline stimulation of the phosphoinositide system: evidence for a novel hydrophobic inositol‐containing compound in resistance arterioles
- Mutant ras gene induces elevated levels of inositol tris- and hexakisphosphates in Dictyostelium.
- Anion-exchange high-performance liquid chromatographic analysis of inositol phosphates.
- Carbachol stimulates inositol phosphate formation transiently in Trypanosoma cruzi.
- High-performance liquid chromatographic analysis of radiolabeled inositol phosphates.
- Polyphosphoinositides are the major source of inositol phosphates in carbamoylcholine-stimulated SK-N-SH neuroblastoma cells.