Drug solubilizers to aid pharmacologists: amorphous cyclodextrin derivatives.
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Summary
The drugs investigated were dissolved in amounts linearly proportionate to the concentration of the solubilizers used and did not precipitate upon dilution by aqueous media, which may considerably facilitate pharmacological evaluation of new, water insoluble potential drugs.
- Type
- article
- Published
- 1988-01-01
- Cited by
- 245
- References
- 10
- OpenAlex
- https://openalex.org/W2055806250
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19190973
Keywords
Cyclodextrin, Chemistry, Amorphous solid, Aqueous solution, Dilution
References
- The Odorant‐Sensitive Adenylate Cyclase of Olfactory Receptor Cells
- Hydrophilic cyclodextrin derivatives enable effective oral administration of steroidal hormones.
- Improvement of dissolution and absorption characteristics of phenytoin by a water-soluble β-cyclodextrin-epichlorohydrin polymer
- Affinity labels for beta-adrenoceptors: preparation and properties of alkylating beta-blockers derived from indole.
- Rescue from hypervitaminosis A or potentiation of retinoid toxicity by different modes of cyclodextrin administration.
- Hydroxypropyl-β-cyclodextrin: preparation and characterization; effects on solubility of drugs
- Amorphous water-soluble derivatives of cyclodextrins: nontoxic dissolution enhancing excipients.
- Solubilization of drugs by modified β-cyclodextrins
- Complexation of several drugs with water-soluble cyclodextrin polymer.
- Stimulation of adenylate cyclase by water-soluble analogues of forskolin.
Cited by
- Ocular pharmacokinetics of saperconazole in rabbits. A potential agent against keratomycoses.
- Effects of Inclusion Complexation on the Transepithelial Transport of a Lipophilic Substance in Vitro
- Cyclodextrins in peptide and protein delivery.
- Vaccinia Virus Penetration Requires Cholesterol and Results in Specific Viral Envelope Proteins Associated with Lipid Rafts
- Chemical Stabilization of a Vasoactive S-Nitrosothiol with Cyclodextrins Without Loss of Pharmacologic Activity
- Cytotoxicity and membrane damage in vitro by inclusion complexes between gamma-cyclodextrin and siloxanes.
- Improved Delivery Through Biological Membranes. XLV. Synthesis, Physical-Chemical Evaluation, and Brain Uptake Studies of 2-Chloroethyl Nitrosourea Delivery Systems
- Effect of 2-Hydroxypropyl-β-cyclodextrin on the Ocular Absorption of Dexamethasone and Dexamethasone Acetate
- Fate of cerium dioxide nanoparticles in endothelial cells: exocytosis
- The Influence of Membrane Lipid Order on Cell Shape and Microvesiculation in Human Erythrocytes
- Effects Of Cholesterol On Bovine Sperm Survival During Cooling and Freezing
- New Perspectives in Cyclodextrin Pharmaceutical Applications
- Alterations in membrane cholesterol that affect structure and function of caveolae.
- Chandipura virus perturbs cholesterol homeostasis leading to neuronal apoptosis
- Assessment of the antiprotozoal activity of some tubulin inhibitors following cyclodextrin complexation
- Effects of methyl-beta-cyclodextrin on cryosurvival of boar spermatozoa.
- Etude du rôle des lysosomes et du cholestérol au cours de la différenciation des kératinocytes épidermiques
- Use of 2-Hydroxypropyl-β-cyclodextrin as a Solubilizing and Stabilizing Excipient for Protein Drugs
- Cryopreservation of bison semen
- Transient Translocation of the B Cell Receptor and Src Homology 2 Domain-Containing Inositol Phosphatase to Lipid Rafts: Evidence Toward a Role in Calcium Regulation1
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