Ocular pharmacokinetics of saperconazole in rabbits. A potential agent against keratomycoses.
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Summary
The ocular pharmacokinetics of saperconazole, an experimental lipophilic triazole with activity against filamentous fungi, were evaluated in rabbits by radioassay and revealed that 44.17% of the drug in the cornea following topical administration was bioactive.
- Type
- article
- Published
- 1992-04-01
- Cited by
- 9
- References
- 12
- OpenAlex
- https://openalex.org/W2081899309
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1674404
Keywords
Cornea, Pharmacokinetics, Clearance, Medicine, Pharmacology
References
- Oral and parenteral therapy with saperconazole (R 66905) of invasive aspergillosis in normal and immunocompromised animals
- Drug solubilizers to aid pharmacologists: amorphous cyclodextrin derivatives.
- The Cornea: Scientific foundations and clinical practice
- Pharmacologic management of keratomycoses.
- Structural degeneration of Aspergillus fumigatus after exposure to saperconazole.
- Pharmacokinetic evaluation of UK-49,858, a metabolically stable triazole antifungal drug, in animals and humans
- Toxicity and Pharmacokinetics of Subconjunctival Amphotericin B: An Experimental Study
- Ocular uptake of fluconazole following oral administration.
- Fluconazole Penetration into Cerebrospinal Fluid in Humans
- Penetration of new azole compounds into the eye and efficacy in experimental Candida endophthalmitis
- Comparative efficacy of new azole antifungal agents against human ocular isolates
Cited by
- The changing spectrum of fungal keratitis in south Florida.
- Advances in the Management of Keratomycosis and Acanthamoeba Keratitis
- Animal models of Aspergillus infection in preclinical trials, diagnostics and pharmacodynamics: What can we learn from them?
- Animal models: an important tool in mycology
- The relationship of corneal epithelial defect size to drug penetration.
- THERAPY OF OCULAR FUNGAL INFECTIONS
- Rabbit Model of Candida Keratomycosis
- Ocular Pharmacokinetics and Pharmacodynamics
- Aspergillose aviaire : développement d’un modèle d’aspergillose chez la dinde (Meleagris gallopavo) et évaluation de l’efficacité de l’énilconazole
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