SREBP in signal transduction: cholesterol metabolism and beyond.
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Summary
A feedback system that enables cholesterol and certain sterol intermediates to regulate the proteolysis and transport of specific membrane proteins is unraveled, revealing the wide-ranging roles that SREBPs and membrane biogenesis have in cell biology.
- Type
- review
- Published
- 2007-04-01
- Cited by
- 298
- References
- 40
- OpenAlex
- https://openalex.org/W2048258966
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23705086
Keywords
Sterol regulatory element-binding protein, Biology, Cell biology, Transcription factor, Proteasome
References
- Sterol Regulatory Element-binding Proteins (SREBPs): Key Regulators of Nutritional Homeostasis and Insulin Action*
- Sterol-regulated Degradation of Insig-1 Mediated by the Membrane-bound Ubiquitin Ligase gp78*
- The SREBP pathway — insights from insigs and insects
- Activation Domains from Both Monomers Contribute to Transcriptional Stimulation by Sterol Regulatory Element-binding Protein Dimers*
- A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood.
- An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis
- Hyperphosphorylation regulates the activity of SREBP1 during mitosis.
- Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis.
- Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol.
- Sterol regulatory element-binding protein 1 is negatively modulated by PKA phosphorylation.
- Regulatory Role of Glycogen Synthase Kinase 3 for Transcriptional Activity of ADD1/SREBP1c*
- Insig Required for Sterol-mediated Inhibition of Scap/SREBP Binding to COPII Proteins in Vitro*♦
- Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7).
- Transcriptional regulation of phagocytosis-induced membrane biogenesis by sterol regulatory element binding proteins.
- PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP
- Regulation of gene expression by SREBP and SCAP.
- Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines.
- RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene
- Cdk1/Cyclin B-Mediated Phosphorylation Stabilizes SREBP1 During Mitosis
- Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase.
Cited by
- Transcriptional regulation of hepatic fatty acid metabolism.
- A new player in the orchestra of cell growth: SREBP activity is regulated by mTORC1 and contributes to the regulation of cell and organ size.
- hnRNP A1 mediates the activation of the IRES-dependent SREBP-1a mRNA translation in response to endoplasmic reticulum stress.
- Sterol regulatory element binding proteins: their role in the hypoxic response of cancer cells and their regulation by the Akt/mTORC1 pathway
- Impacts de perturbations de l'homéostasie lipidique sur la fonctionnalité de la voie de secrétion chez la levure Saccharomyces cerevisiae
- Managing biological data in pathways and networks
- Regulation of hepatic ER stress by the E3 ubiquitin ligase gp78 in zebrafish
- Clock genes and biological rhythms. Effects of psychotropic drugs
- The role of the c-Jun ubiquitin ligase Fbw7 in the nervous system
- An investigation into the regulation of gene expression in response to ER stress
- Identification of metabolic genes essential for proliferation of clear cell Renal Cell Carcinoma (ccRCC) cells
- The Role of ER Stress and the Unfolded Protein Response in Obesity Associated Type 2 Diabetes
- Investigating mechanisms of environmental chemical tolerance and toxicity in brown trout using RNA-seq
- The health benefits of sweet lupin seed flours and isolated proteins
- SREBP-1 is a novel mediator of TGFβ1 signaling in mesangial cells.
- Presenilin complexes in Arabidopsis : novel plant cell-signalling components?
- Alternative Processing of SREBP in Site 2 Protease and Scap Mutants During Larval Development in Drosophila Melanogaster
- Modulación metabólica de la oleoil estrona en ratas con sobrepeso
- A Whole Genome RNAi Screen to Identify Novel Promoters of PINK1/Parkin-mediated Mitophagy
- Novel genes in cell cycle control and lipid metabolism with dynamically regulated binding sites for sterol regulatory element‐binding protein 1 and RNA polymerase II in HepG2 cells detected by chromatin immunoprecipitation with microarray detection
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