PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP
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Summary
The data indicate that activation of SREBP by Akt leads to the induction of key enzymes of the cholesterol and fatty acid biosynthesis pathways, and thus membrane lipid biosynthesis.
- Type
- article
- Published
- 2005-09-29
- Cited by
- 476
- References
- 46
- OpenAlex
- https://openalex.org/W2051823539
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5644057
Keywords
Sterol regulatory element-binding protein, Protein kinase B, Biology, Fatty acid synthesis, Biochemistry
References
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- Lipid rafts and signal transduction
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- Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes DOI 10.1194/jlr.M100417-JLR200
- Activation Domains from Both Monomers Contribute to Transcriptional Stimulation by Sterol Regulatory Element-binding Protein Dimers*
- Fatty acid synthase expression in endometrial carcinoma
- A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood.
- Androgens, lipogenesis and prostate cancer.
- AKT Activity Determines Sensitivity to Mammalian Target of Rapamycin (mTOR) Inhibitors by Regulating Cyclin D1 and c-myc Expression*
- NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation.
- Sterol-dependent Transcriptional Regulation of Sterol Regulatory Element-binding Protein-2*
- Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients
- Cholesterol and prostate cancer
- Liver-specific mRNA for Insig-2 down-regulated by insulin: Implications for fatty acid synthesis
- Sterol Regulation of Fatty Acid Synthase Promoter
- Selective Association of Sterol Regulatory Element-binding Protein Isoforms with Target Promoters in Vivo*
- Differential regulation of endogenous glucose-6-phosphatase and phosphoenolpyruvate carboxykinase gene expression by the forkhead transcription factor FKHR in H4IIE-hepatoma cells.
- Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B.
- Differential Regulation of Sterol Regulatory Element-binding Protein 1c Transcriptional Activity by Insulin and Liver X Receptor during Liver Development*
Cited by
- Overexpression of Fatty Acid Synthase in Middle Eastern Epithelial Ovarian Carcinoma Activates AKT and Its Inhibition Potentiates Cisplatin-Induced Apoptosis
- Transcriptional regulation of hepatic fatty acid metabolism.
- 1-11C-Acetate as a PET Radiopharmaceutical for Imaging Fatty Acid Synthase Expression in Prostate Cancer
- A new player in the orchestra of cell growth: SREBP activity is regulated by mTORC1 and contributes to the regulation of cell and organ size.
- Activated α2-Macroglobulin Binding to Human Prostate Cancer Cells Triggers Insulin-like Responses
- Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP
- Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver
- OSBP-related protein-2 (ORP2): a novel Akt effector that controls cellular energy metabolism
- L-Lysine Attenuates Hepatic Steatosis in Senescence-Accelerated Mouse Prone 8 Mice.
- Sterol regulatory element binding proteins: their role in the hypoxic response of cancer cells and their regulation by the Akt/mTORC1 pathway
- Characterization of a novel inhibitor of fatty acid synthase in malignant, immortalized and normal ovarian surface epithelial cells
- NOVEL THERAPEUTIC TARGETS IDENTIFIED BY HIGH-THROUGHPUT TECHNOLOGIES FOR TRIPLE-NEGATIVE BREAST CANCER
- Fatty acid synthase activity in tumor cells.
- Analyzing the effects of single and mixtures of potato glycoalkaloids on gene expression in intestinal epithelial cells
- Transcriptional regulation by insulin: from the receptor to the gene.
- Inhibiting Tumor Protein D52 function for anti-cancer therapy application
- The study of RAS-induced metabolic reprogramming and the role of the pentose phosphate pathway in tumor metabolism
- Effects in an experimental model of colon cancer and intake in the Finnish population
- Nanoparticles can induce changes in the intracellular metabolism of lipids without compromising cellular viability
- SREBP-1 is a novel mediator of TGFβ1 signaling in mesangial cells.
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