Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation
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Summary
It is proposed that the singular phosphorylation of the amino-terminus of histone H3 may be involved in facilitating two key functions during mitosis: (1) regulate protein-protein interactions to promote binding of trans-acting factors that “drive” chromatin condensation as cells enter M-phase and (2) coordinate chromatin decondensation associated with M- phase.
- Type
- article
- Published
- 1997-10-30
- Cited by
- 1,967
- References
- 55
- OpenAlex
- https://openalex.org/W2048109276
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29723188
Keywords
Premature chromosome condensation, Prophase, Histone H3, Mitosis, Biology
References
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- Mutation of the zebrafish glass onion locus causes early cell-nonautonomous loss of neuroepithelial integrity followed by severe neuronal patterning defects in the retina.
- The temporal and spatial pattern of histone H3 phosphorylation at serine 28 and serine 10 is similar in plants but differs between mono- and polycentric chromosomes
- The Murine Ortholog of Notchless, a Direct Regulator of the Notch Pathway in Drosophila melanogaster, Is Essential for Survival of Inner Cell Mass Cells
- How to build a centromere: from centromeric and pericentromeric chromatin to kinetochore assembly.
- Condensin I Reveals New Insights on Mouse Meiotic Chromosome Structure and Dynamics
- Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1
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- The dendritic polymer DAB-Am16 as a novel tumoricidal compound
- The physics behind the larger scale organization of DNA in eukaryotes
- Visualization of DNA methylation and histone modifications in living cells.
- Evaluation of the proliferation markers Ki-67/MIB-1, mitosin, survivin, pHH3, and DNA topoisomerase IIα in human anaplastic astrocytomas - an immunohistochemical study
- ERK1/2 Signaling Plays an Important Role in Topoisomerase II Poison-Induced G2/M Checkpoint Activation
- Amitozyn Impairs Chromosome Segregation and Induces Apoptosis via Mitotic Checkpoint Activation
- Distribution pattern of histone H3 phosphorylation at serine 10 during mitosis and meiosis in Brachiaria species
- Small coelomic epithelial cells of the starfish Asterias rubens L. that are able to proliferate in vivo and in vitro
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