PKR; a sentinel kinase for cellular stress

Keywords

Protein kinase R, Biology, EIF-2 kinase, RNA silencing, Stress granule

References

• Specific Mutations Near the Amino Terminus of Double-stranded RNA-dependent Protein Kinase (PKR) Differentially Affect Its Double-stranded RNA Binding and Dimerization Properties*Claudio Corradi — 1996
• Structure of the dsRNA binding domain of E. coli RNase III.A. Kharrat, María J. Macias, Toby J. Gibson — 1995
• Abrogation of translation initiation factor eIF‐2 phosphorylation causes malignant transformation of NIH 3T3 cells.Olivier Donzé, Rosemary Jagus, Antonis E. Koromilas — 1995
• Mechanism of Interferon Action: Biochemical and Genetic Evidence for the Intermolecular Association of the RNA-Dependent Protein Kinase PKR from Human CellsLaura G. Ortega, MATTHEW D. MCCOTTER, GILBERT L. HENRY — 1996
• NMR solution structure of a dsRNA binding domain from Drosophila staufen protein reveals homology to the N‐terminal domain of ribosomal protein S5.Mark Bycroft, Stefan Grünert, Alexey G. Murzin — 1995
• Stress responses: Translational control perks upRobert H. Silverman, Bryan Williams — 1999
• Aberrant expression of double-stranded RNA-dependent protein kinase in hepatocytes of chronic hepatitis and differentiated hepatocellular carcinoma.Akira Shimada, Goshi Shiota, Hironori Miyata — 1998
• Possible involvement of double-stranded RNA-activated protein kinase in cell death by influenza virus infectionT. Takizawa, Kayoko Ohashi, Yoshinobu Nakanishi — 1996
• Platelet-derived Growth Factor Signal Transduction through the Interferon-inducible Kinase PKRL.J. Mundschau, Douglas V. Faller — 1995
• Double-Stranded-RNA-Activated Protein Kinase PKR Enhances Transcriptional Activation by Tumor Suppressor p53Andrew Cuddihy, Suiyang Li, Nancy Wai Ning Tam — 1999
• Structure and regulation of eukaryotic initiation factor eIF-2. Sequence of the site in the alpha subunit phosphorylated by the haem-controlled repressor and by the double-stranded RNA-activated inhibitor.David R. Colthurst, David G. Campbell, Christopher G. Proud — 1987
• Inhibition of Double-Stranded RNA- and Tumor Necrosis Factor Alpha-Mediated Apoptosis by Tetratricopeptide Repeat Protein and Cochaperone P58IPKNorina Tang, Marcus J. Korth, Michael Gale — 1999
• Two functionally distinct RNA-binding motifs in the regulatory domain of the protein kinase DAISimon R. Green, Lisa Manche, Michael B. Mathews — 1995
• The eIF‐2α kinases and the control of protein synthesis 1César de Haro, Raúl Méndez, Javier Santoyo‐López — 1996
• RAX, a Cellular Activator for Double-stranded RNA-dependent Protein Kinase during Stress Signaling*Takahiko Ito, Mingli Yang, W. Stratford May — 1999
• Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.Ashutosh Kumar, Jaharul Haque, Judith Lacoste — 1994
• Double-stranded (ds) RNA Binding and Not Dimerization Correlates with the Activation of the dsRNA-dependent Protein Kinase (PKR) (*)Shiyong Wu, Randal J. Kaufman — 1996
• PACT, a protein activator of the interferon‐induced protein kinase, PKRRamesh C. Patel, Ganes C. Sen — 1998
• Cell cycle regulation of the double stranded RNA activated protein kinase, PKRMaryam Zamanian-Daryoush, Sandy D. Der, Bryan R.G. Williams — 1999
• A cytokine-responsive IκB kinase that activates the transcription factor NF-κBJoseph A. DiDonato, Makio Hayakawa, David M. Rothwarf — 1997

Cited by

• A study of novel biomarkers of hepatitis C related liver injuryWassim Abdul Rahman — 2013
• PACT, a Stress-modulated Cellular Activator of Interferon-induced Double-stranded RNA-activated Protein Kinase, PKR*廖建文 — 2000
• A dynamically tuned double‐stranded RNA binding mechanism for the activation of antiviral kinase PKRGavin Wright — 2000
• RuNAway Disease: A two cycle model for transmissible spongiform encephalopathies (TSEs) wherein SINE proliferation drives PrP overproductionOlga Ivanovna Davidan — 2001
• Punta Toro Virus Infection in Mice: Strain Differences in Pathogenesis and Regulation of Interferon Response PathwaysMichelle Mendenhall — 2009
• The ZO-1–associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density泉 竹吉, 進 大和田, 哲史 小川 — 2003
• Infectious triggers of pediatric asthma.Pär Gustafsson — 2003
• Counteraction of interferon-induced antiviral responses by herpes simplex viruses.David A. Leib — 2002
• Viral respiratory infection and the link to asthmaFrank E. Ritter — 2004
• PACT-Mediated Enhancement of Reporter Gene Expression at the Translational LevelManmohan Sharma, S. V. Bali, D K Gupta — 2003
• Global gene expression as a function of germline genetic variation.Julia García Verdugo — 2005
• Influenza Virus Infection Increases p53 Activity: Role of p53 in Cell Death and Viral ReplicationPaul B. Cissna, June Evans — 2005
• The Leader Proteinase of Foot-and-Mouth Disease Virus Inhibits the Induction of Beta Interferon mRNA and Blocks the Host Innate Immune ResponseAntonius Wibowo — 2006
• Untersuchungen zum Einsatz von small interfering RNAs gegen epidermal growth factor receptor in humanen GliomzellenArabel Vollmann — 2004
• Characterization of the Cellular and Molecular Factors Mediating Antigen-Independent Noncytolytic CD8+ T Cell Suppression of HIV-1Ashwin Tumne — 2006
• Photophysical and calorimetric studies on the binding of 9-O-substituted analogs of the plant alkaloid berberine to double stranded poly(A).Danielle Malek Roosa — 2013
• Chicken melanoma differentiation-associated gene 5 (MDA5) recognizes infectious bursal disease virus infection and triggers MDA5-related innate immunityLuis de la Corte Ibáñez — 2014
• Pathogenic Viruses: Smart Manipulators of the Interferon SystemOtto Haller, Friedemann Weber — 2007
• HCV Regulation of Host DefenseD. Spencer Carney, Michael Gale — 2006
• Augmenting antiviral host defense in the respiratory epitheliumAnthony J. Fischer — 2009

Related papers

• The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assemblyCarmela Sidrauski, Anna McGeachy, Nicholas T. Ingolia — 2015
• Dihydrocapsaicin induces translational repression and stress granule through HRI-eIF2α phosphorylation axis.Koushitak De, Aravinth Kumar Jayabalan, Ramesh Mariappan — 2021
• Integrated stress response of vertebrates is regulated by four eIF2α kinasesShusuke Taniuchi, Masato Miyake, Kazue Tsugawa — 2016
• Translation inhibition and stress granules in the antiviral immune responseCraig McCormick, Denys A. Khaperskyy — 2017
• Quercetin Regulates the Integrated Stress Response to Improve MemoryToshiyuki Nakagawa, Kazunori Ohta — 2019
• Stress Granules Regulate Double-Stranded RNA-Dependent Protein Kinase Activation through a Complex Containing G3BP1 and Caprin1Lucas C. Reineke, Nancy Kedersha, Martijn A. Langereis — 2015
• The double‐stranded RNA‐dependent protein kinase PKR negatively regulates the protein expression of IFN‐β induced by RIG‐I signalingTomoh Matsumiya, Yuko Shiba, Jiangli Ding — 2023
• Induction of Stress Granules by Interferon and Down-regulation by the Cellular RNA Adenosine Deaminase ADAR1Lijo John, Charles E. Samuel — 2014
• Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress ResponsesHuib H. Rabouw, Martijn A. Langereis, Robert C. M. Knaap — 2016