A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
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Summary
IKK turns out to be the long-sought-after protein kinase that mediates the critical regulatory step in NF-κB activation, and phosphorylates IκBs on the sites that trigger their degradation.
- Type
- article
- Published
- 1997-08-07
- Cited by
- 2,118
- References
- 32
- Access
- Open access
- OpenAlex
- https://openalex.org/W1979520552
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4354442
Keywords
IκB kinase, NF-κB, Transcription factor, Cell biology, MAP kinase kinase kinase
References
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- JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.
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- Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination.
- TRAF6 is a signal transducer for interleukin-1
- Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death
- c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions.
- Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation
- IRAK: A Kinase Associated with the Interleukin-1 Receptor
- Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.
- In vivo stimulation of I kappa B phosphorylation is not sufficient to activate NF-kappa B
- Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation
- Function and activation of NF-kappa B in the immune system.
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- The role of protein phosphatases in the expression of inducible nitric oxide synthase in the rat hepatocyte
- Aminosalicylic Acid Inhibits IκB Kinase α Phosphorylation of IκBα in Mouse Intestinal Epithelial Cells*
- Cell type-specific role for reactive oxygen species in nuclear factor-kappaB activation by interleukin-1.
- NFAT1 enhances HIV-1 gene expression in primary human CD4 T cells.
- Toll‐like receptors: molecular mechanisms of the mammalian immune response
- Specificity, diversity, and convergence in VEGF and TNF‐α signaling events leading to tissue factor up regulation via EGR‐1 in endothelial cells
- Selective Retinoids That Inhibit IKK as Chemotherapeutic Agents Against Estrogen-Independent Breast Cancer Cells
- BCL-6 negatively regulates macrophage proliferation by suppressing autocrine IL-6 production.
- Interleukin-1 stimulates cytokines, prostaglandin E2 and matrix metalloproteinase-1 production via activation of MAPK/AP-1 and NF-kappaB in human gingival fibroblasts.
- Bioactive sphingolipids in the modulation of the inflammatory response.
- Interferon action and the double-stranded RNA-dependent enzymes ADAR1 adenosine deaminase and PKR protein kinase.
- The gender‐related differences in the incidence of development of respiratory complications, and the role of estrogen
- FAF1 Suppresses IκB Kinase (IKK) Activation by Disrupting the IKK Complex Assembly*
- Molecular mechanism of signaling by tumor necrosis factor
- Acute immunomodulatory effects of iron polyisomaltosate in rats.
- Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-kappaB p65 in LPS signaling pathway.
- NF-kappaB as a prognostic marker and therapeutic target in chronic lymphocytic leukemia.
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