The LKB1-AMPK pathway: metabolism and growth control in tumor suppression
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Summary
The connection of AMPK with several tumour suppressors suggests that therapeutic manipulation of this pathway using established diabetes drugs warrants further investigation in patients with cancer.
- Type
- review
- Published
- 2009-08-01
- Cited by
- 1,950
- References
- 203
- Access
- Open access
- OpenAlex
- https://openalex.org/W2044874695
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:32536572
Keywords
AMPK, Protein kinase A, Lipid metabolism, Cell biology, Signal transduction
References
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- The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry.
- AMP-activated Protein Kinase Phosphorylates and Desensitizes Smooth Muscle Myosin Light Chain Kinase*♦
- The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid β-oxidation
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- Regulation of LKB1/STRAD localization and function by E-cadherin
- Using kinomics to delineate signaling pathways: Control of crtc2/torc2 by the ampk family
- Cdc42 and noncanonical Wnt signal transduction pathways cooperate to promote cell polarity
- LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons.
- The p53-regulated Sestrin gene products inhibit mTOR signaling
- The Energy Sensor AMP-activated Protein Kinase Directly Regulates the Mammalian FOXO3 Transcription Factor*
- Lkb1 is required for TGFβ-mediated myofibroblast differentiation
- Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation
Cited by
- Developing a systems-based understanding of hematopoietic stem cell cycle control.
- ON T CELL FATE DECISIONS: RETINOL, METABOLISM AND ITREG DIFFERENTIATION
- Metformin and its clinical use: new insights for an old drug in clinical practice
- Regulation of metformin response by breast cancer associated gene 2.
- LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor
- Activation of AMP-kinase by AICAR induces apoptosis of DU-145 prostate cancer cells through generation of reactive oxygen species and activation of c-Jun N-terminal kinase.
- LKB1 Represses Focal Adhesion Kinase (FAK) Signaling via a FAK-LKB1 Complex to Regulate FAK Site Maturation and Directional Persistence*
- Targeting the PI3-kinase/Akt/mTOR Signaling Pathway
- Oxford and the Savannah: Can the Hippo Provide an Explanation for Peto's Paradox?
- Convergence of IPMK and LKB1-AMPK signaling pathways on metformin action.
- Clinical impact of the Warburg effect in gastrointestinal cancer (review).
- Reduced expression of liver kinase B1 and Beclin1 is associated with the poor survival of patients with non-small cell lung cancer.
- n-3 Polyunsaturated Fatty Acids and Mechanisms to Mitigate Inflammatory Paracrine Signaling in Obesity-Associated Breast Cancer
- The PI3K/Akt/mTOR pathway in ovarian cancer: therapeutic opportunities and challenges
- Metformin induces degradation of cyclin D1 via AMPK/GSK3β axis in ovarian cancer
- miRNA-451 inhibits glioma cell proliferation and invasion by downregulating glucose transporter 1
- Repurposing phenformin for the targeting of glioma stem cells and the treatment of glioblastoma
- AICAR induces mitochondrial apoptosis in human osteosarcoma cells through an AMPK-dependent pathway
- Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy
- Sirolimus and Metformin Synergistically Inhibits Colon Cancer In Vitro and In Vivo
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