Polycyclic aromatic hydrocarbons physically intercalate into duplex regions of denatured DNA.
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Summary
It appears that physical binding of polycyclic aromatic hydrocarbons consists of intercalation into these sites, and increasing salt concentration increases the duplex content of denatured DNA.
- Type
- article
- Published
- 1987-10-06
- Cited by
- 1,950
- References
- 35
- OpenAlex
- https://openalex.org/W2044851985
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27299553
Keywords
Intercalation (chemistry), Chemistry, DNA, Pyrene, Binding constant
References
- Covalent binding of isomeric benzo[a]pyrene diol-epoxides to DNA.
- Characterization of reversible, physical binding of benzo[a]pyrene derivatives to DNA.
- Na+ effects on transitions of DNA and polynucleotides of variable linear charge density
- Reaction of the 7,8-diol 9,10-epoxide of benzo(a)pyrene with guanine in DNA. Ab initio calculations and proposed reaction mechanism
- Noncovalent intercalative complex formation and kinetic flow linear dichroism of racemic syn- and anti-benzo[a]pyrenediol epoxide-DNA solutions.
- SECONDARY STRUCTURE IN RIBONUCLEIC ACIDS.
- Kinetic and hydrodynamic studies of the complex of proflavine with poly A·poly U
- Mechanisms of reaction of benzo(a)pyrene-7,8-diol-9,10-epoxide with DNA in aqueous solutions.
- Analysis of cooperativity and ion effects in the interaction of quinacrine with DNA
- Properties of benzopyrene-DNA complexes investigated by fluorescence and triplet flash phytolysis techniques.
- Benzo[a]pyrene-7,8-dihydrodiol: selective binding to single stranded DNA and inactivation of 0X174 DNA infectivity.
- Conformational changes of single-stranded DNA.
- Physical binding of tetraols derived from 7,8-dihydroxy-9,10-epoxybenzo[a]pyrene to DNA
- A simple method for studying the solubilization of polycyclic aromatic hydrocarbons in DNA solutions.
- Polarized fluorescence of polycyclic hydrocarbons in aqueous DNA solutions: Effect of flow-orientation
- The binding of benzo[a]pyrene-7,8-dihydrodiol to bacteriophage phi X174 DNA.
- Rapid kinetic studies on the conformation of single‐stranded DNA
- Electric linear dichroism study on the orientation of benzo[alpha]pyrene-7,8-dihydrodiol 9,10-oxide covalently bound to DNA.
- Catalysis of carcinogen-detoxification by DNA: comparison of enantiomeric diol epoxides.
- Intercalative DNA binding of model compounds derived from metabolites of 7,12-dimethylbenz[a]anthracene.
Cited by
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- Synthesis, characterization and biological activity of lanthanum(III) complexes containing 2-methylene-1,10-phenanthroline units bridged by aliphatic diamines.
- Ruthenium(II) mixed-ligand complex containing 2-(4'-benzyloxy-phenyl)imidazo[4,5-f][1,10]phenanthroline: synthesis, DNA-binding and photocleavage studies.
- One-dimensional copper(II) coordination polymers bridged both by mu-trans-oxamidates and phenyldicarboxylates: Synthesis, crystal structure and DNA binding studies.
- DNA binding studies of PdCl2(LL)(LL = chelating diamine ligand: N,N-dimethyltrimethylenediamine) complex
- Synthesis, crystal structure, cytotoxic activities and DNA-binding properties of new binuclear copper(II) complexes bridged by N,N'-bis(N-hydroxyethylaminoethyl)oxamide.
- Synthesis and Biophysical Studies of Bis‐Macrocyclic Cobalt/Copper(II) Complexes Having a Pyridine Spacer with CT DNA and 5′‐GMP
- Synthesis, Characterization Luminiscence Studies and Microbial Activity of Ethylenediamine Ruthenium (II) Complexes with Dipyridophenazine Ligands
- Synthesis, structure, DNA-binding properties and antioxidant activity of a nickel(II) complex with bis(N-allylbenzimidazol-2-ylmethyl)benzylamine.
- Cytotoxic Activities and DNA Binding Properties of 1-Methyl-7H-indeno[1,2-b]Quinolinium-7-(4-dimethylamino) Benzylidene Triflate
- Syntheses and structures of new trimetallic complexes bridged by N-(5-chloro-2-hydroxyphenyl)-N'-[3-(dimethylamino)propyl]oxamide: cytotoxic activities, and reactivities towards DNA and protein.
- A systematic investigation on biological activities of a novel double zwitterionic Schiff base Cu(II) complex.
- Synthesis, crystal structure and antiproliferative activity of Cu(II) nalidixic acid-DACH conjugate: comparative in vitro DNA/RNA binding profile, cleavage activity and molecular docking studies.
- Synthesis and crystal structure of new dicopper(II) complexes with N,N'-bis-(dipropylenetriamine)oxamide as bridging ligand: effects of the counterions on DNA/protein-binding property and in vitro antitumor activity.
- Rational design of a cytotoxic dinuclear Cu2 complex that binds by molecular recognition at two neighboring phosphates of the DNA backbone.
- Targeting human telomeric and c-myc G-quadruplexes with alkynylplatinum(II) terpyridine complexes under molecular crowding conditions.
- Synthesis and Characterization of Oxidovanadium(IV) Complexes of 2-((E)-(6-Fluorobenzo[d]thiazol-2-ylimino)methyl)-6-methoxyphenol and Their Antimicrobial, Antioxidant, and DNA-Binding Studies
- 1,3-dimethyl-6-nitroacridine derivatives induce apoptosis in human breast cancer cells by targeting DNA
- Silver Nanoparticles Inhibit Hepatitis B virus Replication
- Interaction of Pyrimoidiazolium Ions with Calf Thymus DNA
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