The regulation of AMP-activated protein kinase by phosphorylation.
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Summary
It is shown that AMPKK phosphorylates at least two other sites on the alpha subunit and one site on the beta subunit, and evidence that phosphorylation of Thr(172) may be involved in the sensitivity of the AMPK complex to AMP is provided.
- Type
- article
- Published
- 2000-02-01
- Cited by
- 623
- References
- 10
- Access
- Open access
- OpenAlex
- https://openalex.org/W1972762474
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8780019
Keywords
Protein kinase A, AMPK, Phosphorylation, AMP-activated protein kinase, Alanine
References
Cited by
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- Antidiabetic and Antihyperlipidemic Effects of Clitocybe nuda on Glucose Transporter 4 and AMP-Activated Protein Kinase Phosphorylation in High-Fat-Fed Mice
- The beneficial effects of AMP kinase activation against oxidative stress are associated with prevention of PPARα-cyclophilin D interaction in cardiomyocytes.
- Ergostatrien-3β-ol from Antrodia camphorata inhibits diabetes and hyperlipidemia in high-fat-diet treated mice via regulation of hepatic related genes, glucose transporter 4, and AMP-activated protein kinase phosphorylation.
- Amarogentin, a secoiridoid glycoside, activates AMP- activated protein kinase (AMPK) to exert beneficial vasculo-metabolic effects.
- Expression and regulation of the AMP-activated protein kinase-SNF1 (sucrose non-fermenting 1) kinase complexes in yeast and mammalian cells: studies using chimaeric catalytic subunits.
- Sepsis and AMPK Activation by AICAR Differentially Regulate FoxO-1, -3 and -4 mRNA in Striated Muscle.
- AMPK as a Potential Anticancer Target – Friend or Foe?
- Insulin receptor, AMPK and CPT-2: Crystallization experiments and structural characterization of three proteins relevant to diabetes mellitus
- Molecular biology of the stress response in the early embryo and its stem cells.
- The activation of AMPK in cardiomyocytes at the very early stage of hypoxia relies on an adenine nucleotide-independent mechanism.
- The Role of PJA2-CDK5R1 in β-cell Function
- The Effects of Chromium on Skeletal Muscle Membrane/Cytoskeletal Parameters and Insulin Sensitivity
- AMPK activators regulate contractile function of mesenteric arteries
- LKB1/ AMPK / TSC2 signaling pathway alterations in non-small-cell-lung-carcinoma
- Regulation and role of the LKB1-AMPK pathway
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