Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression
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Summary
A meta-analysis of the interaction between the serotonin transporter gene and stressful life events on depression yielded no evidence that the serotonin transporter genotype alone or in interaction with stressful life events is associated with an elevated risk of depression in men alone, women alone, or in both sexes combined.
- Type
- review
- Published
- 2009-06-17
- Cited by
- 1,758
- References
- 97
- Access
- Open access
- OpenAlex
- https://openalex.org/W2042170262
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3900912
Keywords
Serotonin transporter, Medicine, Meta-analysis, 5-HTTLPR, Context (archaeology)
References
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- Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with selective serotonin reuptake inhibitor efficacy in depressed patients
- Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism
- The BDNF Val66Met × 5‐HTTLPR × child adversity interaction and depressive symptoms: An attempt at replication
- Family Based Association Analyses between the Serotonin Transporter Gene Polymorphism (5-HTTLPR) and Neuroticism, Anxiety and Depression
- Replicating genotype–phenotype associations
- Proceeding From Observed Correlation to Causal Inference: The Use of Natural Experiments
Cited by
- An Overview of Psychological and Neurobiological Mechanisms by which Early Negative Experiences Increase Risk of Mood Disorders.
- Serotonin-related pathways and developmental plasticity: relevance for psychiatric disorders
- Childhood Stress, Serotonin Transporter Gene and Brain Structures in Major Depression
- Life Course Perspectives on the Epidemiology of Depression
- The Serotonin Transporter Promoter Variant (5-HTTLPR), Stress, and Depression Meta-Analysis Revisited: Evidence of Genetic Moderation
- Bright-Light Therapy in the Treatment of Mood Disorders
- Moderation of adult depression by the serotonin transporter promoter variant (5‐HTTLPR), childhood abuse and adult traumatic events in a general population sample
- Support for involvement of glutamate decarboxylase 1 and neuropeptide y in anxiety susceptibility
- Serotonin transporter 5-HTTLPR genotype moderates the effects of childhood adversity on posttraumatic stress disorder risk: a replication study
- Does Personality Moderate Reaction and Adaptation to Major Life Events? Evidence from the British Household Panel Survey
- Gene–Environment Interactions and Intermediate Phenotypes: Early Trauma and Depression
- Neurobiologie depressiver Störungen
- Reply To: The Liptak-Stouffer Test for Meta-Analyses
- Association between childhood adversities and long-term suicidality among South Africans from the results of the South African Stress and Health study: a cross-sectional study
- Depressive symptoms among children and adolescents in western china: An epidemiological survey of prevalence and correlates.
- Gene–environment interaction of monoamine oxidase A in relation to antisocial behaviour: current and future directions
- Joint Analysis of Multiple Interaction Parameters in Genetic Association Studies
- Genetics of Resilience: Gene-by-Environment Interaction Studies as a Tool to Dissect Mechanisms of Resilience.
- Neural circuits, neurotransmitters, and behavior: serotonin and temperament in bulimic syndromes.
- Gene—Environment Interactions in Major Depressive Disorder
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