Gene—Environment Interactions in Major Depressive Disorder
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Summary
Evidence suggesting that genetic variants moderate the effects of adversities on the development of MDD is reviewed, with a focus on the importance of careful characterization of the stressful life events as well as systemic and molecular mechanisms that potentially mediate these gene–environment interactions.
- Type
- review
- Published
- 2013-02-01
- Cited by
- 116
- References
- 101
- Access
- Open access
- OpenAlex
- https://openalex.org/W42198781
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20671098
Keywords
Major depressive disorder, Humanities, Psychology, Psychiatry, Philosophy
References
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- The runner-up: On the role of the mineralocorticoid receptor in human cognition
- The interaction between stress and genetic factors in the etiopathogenesis of depression
- The role of specific early trauma in adult depression: A meta-analysis of published literature. Childhood trauma and adult depression
- Genetic polymorphism in pathogenesis of irritable bowel syndrome.
- Epigenetics of Stress-Related Psychiatric Disorders and Gene × Environment Interactions.
- Stress-induced anhedonia is associated with the activation of the inflammatory system in the rat brain: Restorative effect of pharmacological intervention.
- Case-control study of glucocorticoid receptor and corticotrophin-releasing hormone receptor gene variants and risk of perinatal depression
- The role of DNA methylation in stress-related psychiatric disorders.
- Type I interferon signaling genes in recurrent major depression: increased expression detected by whole-blood RNA sequencing
- Animal models of major depression and their clinical implications.
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- Data calibration and reduction allows to visualize behavioural profiles of psychosocial influences in mice towards clinical domains
- The Effect of Short Moderate Stress on the Midbrain CRF System in a Macaque Model of Functional Hypothalamic Amenorrhea
- Serotonin transporter genotype, salivary cortisol, neuroticism and life events: impact on subsequent psychopathology in healthy twins at high and low risk for affective disorder.
- Fibroblasts from patients with major depressive disorder show distinct transcriptional response to metabolic stressors
- Interactions between the apolipoprotein E ε4 allele status and adverse childhood experiences on depressive symptoms in older adults