Mendelian randomization in health research: Using appropriate genetic variants and avoiding biased estimates☆
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Summary
This work model potential biases that may arise in Mendelian randomization analysis and concludes that genetic variants should robustly associate with exposures in independent samples and can suggest causality despite no true associations.
- Type
- article
- Published
- 2014-03-01
- Cited by
- 173
- References
- 53
- Access
- Open access
- OpenAlex
- https://openalex.org/W2041215109
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1022487
Keywords
Mendelian randomization, Confounding, Causal inference, Causality (physics), Instrumental variable
References
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- Associations of mortality with own height using son's height as an instrumental variable
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- Smoking and Body Weight: Evidence using Genetic Instruments
- A Genetic Instrumental Variables Analysis of the Effects of Prenatal Smoking on Birth Weight: Evidence from Two Samples
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- A Survey of Weak Instruments and Weak Identification in Generalized Method of Moments
- MEDIATING EFFECTS OF SMOKING AND CHRONIC OBSTRUCTIVE AIRWAY DISEASE ON THE RELATIONSHIP BETWEEN THE CHRNA5-A3 GENETIC LOCUS AND LUNG CANCER RISK
- A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity
Cited by
- Association between gut microbiota and hepatocellular carcinoma and biliary tract cancer: A mendelian randomization study
- Genetically Predicted Testosterone and Systemic Inflammation in Men: A Separate-Sample Mendelian Randomization Analysis in Older Chinese Men
- Evaluation of an association between plasma total homocysteine and schizophrenia by a Mendelian randomization analysis
- Understanding the Candidate Gene × Environment Interaction Debate: Epistemological or evidential divide?
- Using molecular genetic information to infer causality in observational data: Mendelian randomisation
- Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium
- Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
- Genetic markers as instrumental variables
- High tobacco consumption lowers body weight: a Mendelian randomization study of the Copenhagen General Population Study.
- High tobacco consumption is causally associated with increased all-cause mortality in a general population sample of 55,568 individuals, but not with short telomeres: a Mendelian randomization study.
- Author's reply: Considerations of context, distractions by politics and evaluations of evidence.
- Integration of Molecular Pathology, Epidemiology, and Social Science for Global Precision Medicine
- Effect of Smoking on Blood Pressure and Resting Heart Rate: A Mendelian Randomisation Meta-Analysis in the CARTA Consortium
- Mendelian randomization studies: a review of the approaches used and the quality of reporting.
- A Mendelian randomization study of testosterone and cognition in men
- Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies
- Genetic Determinants of Obesity in Relation to Diet, Weight Gain and Mortality
- Plasma levels of vitamin K and the risk of ischemic heart disease: a Mendelian randomization study
- Genetic Instruments for Body Mass Index
- Triglycerides and Triglyceride-Rich Lipoproteins in the Causal Pathway of Cardiovascular Disease.
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