Rapid Temporal Control of Foxp3 Protein Degradation by Sirtuin-1
Explore this paper's citation graph
Summary
It is demonstrated that SIRT1 a member of the lysine deacetylase Sirtuin (SIRT) family, but not the related SIRTs 2–7, co-localize with Foxp3 in the nucleus, and it is shown that Sirt1 inhibition decreasesFoxp3 poly-ubiquitination, thereby increasing Foxp 3 protein levels.
- Type
- article
- Published
- 2011-04-20
- Cited by
- 122
- References
- 41
- Access
- Open access
- OpenAlex
- https://openalex.org/W2041079472
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6235428
Keywords
FOXP3, Sirtuin, Sirtuin 1, Cell biology, Acetylation
References
- CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis.
- Nicotinamide phosphoribosyltransferase/sirtuin 1 pathway is involved in human immunodeficiency virus type 1 Tat‐mediated long terminal repeat transactivation
- Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
- Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells
- Foxp3 occupancy and regulation of key target genes during T-cell stimulation
- The Chemokine and Chemokine Receptor Profile of Infiltrating Cells in the Wall of Arteries With Cardiac Allograft Vasculopathy Is Indicative of a Memory T–Helper 1 Response
- Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization.
- An essential role for Scurfin in CD4+CD25+ T regulatory cells
- TGF-β and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3
- The effect of niacinamide on osteoarthritis: A pilot study
- Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development.
- Generation of potent and stable human CD4+ T regulatory cells by activation-independent expression of FOXP3.
- Inhibition of HDAC9 Increases T Regulatory Cell Function and Prevents Colitis in Mice
- Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function
- Control of Smad7 stability by competition between acetylation and ubiquitination.
- sirt1-null mice develop an autoimmune-like condition.
- Functional Analysis of the Roles of Posttranslational Modifications at the p53 C Terminus in Regulating p53 Stability and Activity
- The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs.
- Histone/protein deacetylase inhibitors increase suppressive functions of human FOXP3+ Tregs
- Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2
Cited by
- Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells
- Genomics, proteomics and metabolomics: their emerging roles in the discovery and validation of rheumatoid arthritis biomarkers.
- Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1
- Mitochondrial sirtuins – a new therapeutic target for repair and protection in multiple sclerosis
- Ubiquitin-dependent regulation of Foxp3 and Treg function
- FOXP3+ Treg Cells and Gender Bias in Autoimmune Diseases
- Seven sirtuins for seven deadly diseases of aging.
- Post-translational modification networks regulating FOXP3 function.
- Targeting Sirtuin-1 Alleviates Experimental Autoimmune Colitis by Induction of Foxp3+ T-Regulatory Cells
- Forkhead Box P Family Members at the Crossroad Between Tolerance and Immunity: A Balancing Act
- Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology
- Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo
- The ascent of acetylation in the epigenetics of rheumatoid arthritis
- Metabolites produced by commensal bacteria promote peripheral regulatory T cell generation
- Treg functional stability and its responsiveness to the microenvironment
- Molecular and biological role of the FOXP3 N-terminal domain in immune regulation by T regulatory/suppressor cells
- Hypoxic culture conditions enhance the generation of regulatory T cells
- Epigenetic Enzymes Are the Therapeutic Targets for CD4+CD25+/highFoxp3+ Regulatory T Cells
- Regulatory T-cell therapy for transplantation: how many cells do we need?
- Ubiquitous Points of Control over Regulatory T cells
Related papers
- Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressors
- Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
- The E. coli sirtuin CobB shows no preference for enzymatic and nonenzymatic lysine acetylation substrate sites
- Toward an Orthogonal Protein Lysine Acylation and Deacylation System
- Effect of caloric restriction on the expression of the Sirtuin Proteins
- Expression of sirtuins in ovarian follicles of postnatal mice
- Sirtuin activators
- Regulation of SIRT1 and Its Roles in Inflammation