Genetic variations of human papillomavirus type 16: implications for cervical carcinogenesis.
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Summary
An extremely sensitive PCR method, differential DNA denaturation PCR, has detected hypermutations from C to T or G to A in the E2 gene and the long control region of the HPV16 genome, which suggests the involvement of cellular apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like (APOBEC) proteins in this hypermutation.
- Type
- review
- Published
- 2015-03-13
- Cited by
- 24
- References
- 54
- Access
- Open access
- OpenAlex
- https://openalex.org/W2040361191
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15359854
Keywords
Biology, Genome, Cervical cancer, Genetics, APOBEC
References
- Genetic Variation of Human Papillomavirus Type 16 in Individual Clinical Specimens Revealed by Deep Sequencing
- In Vivo and In Vitro Studies Suggest a Possible Involvement of HPV Infection in the Early Stage of Breast Carcinogenesis via APOBEC3B Induction
- PATTERNS OF PERSISTENT GENITAL HUMAN PAPILLOMAVIRUS INFECTION AMONG WOMEN WORLDWIDE: A LITERATURE REVIEW AND META-ANALYSIS
- APOBEC3A Functions as a Restriction Factor of Human Papillomavirus
- Long-Term Follow-Up of HPV16-Positive Women: Persistence of the Same Genetic Variant and Low Prevalence of Variant Co-Infections
- High grade cervical lesions are caused preferentially by non‐European variants of HPVs 16 and 18
- Retroviral restriction by APOBEC proteins
- Human Papillomavirus Type 16 Genetic Variants: Phylogeny and Classification Based on E6 and LCR
- Tumourigenesis Driven by the Human Papillomavirus Type 16 Asian-American E6 Variant in a Three-Dimensional Keratinocyte Model
- An APOBEC Cytidine Deaminase Mutagenesis Pattern is Widespread in Human Cancers
- Sequence Imputation of HPV16 Genomes for Genetic Association Studies
- Evidence for Editing of Human Papillomavirus DNA by APOBEC3 in Benign and Precancerous Lesions
- APOBEC-mediated cytosine deamination links PIK3CA helical domain mutations to human papillomavirus-driven tumor development.
- Human papillomavirus type 16 E6 gene variations in Chinese population.
- Human Papillomaviruses: Genetic Basis of Carcinogenicity
- Risk for High-Grade Cervical Intraepithelial Neoplasia Associated with Variants of Human Papillomavirus Types 16 and 18
- Human APOBEC3A Isoforms Translocate to the Nucleus and Induce DNA Double Strand Breaks Leading to Cell Stress and Death
- Human papillomavirus type 16 variants in paired enrollment and follow-up cervical samples: implications for a proper understanding of type-specific persistent infections.
- The immortalizing and transforming ability of two common human papillomavirus 16 E6 variants with different prevalences in cervical cancer
- Oncogenic potential diverge among human papillomavirus type 16 natural variants.
Cited by
- Heat Increases the Editing Efficiency of Human Papillomavirus E2 Gene by Inducing Upregulation of APOBEC3A and 3G.
- Analyse fonctionnelle des polymorphismes du virus du papillome humain de type 33
- Diversité génétique des papillomavirus humains
- Utility of high-throughput DNA sequencing in the study of the human papillomaviruses
- A step towards resolving the mystery of HPV vaccination: breakthrough of cervical cancer
- Findings of multiple HPV genotypes in cervical carcinoma are associated with poor cancer-specific survival in a Swedish cohort of cervical cancer primarily treated with radiotherapy
- Human Papillomavirus Genotypes and HPV16 E6/E7 Variants among Patients with Genital Cancers in Vietnam.
- Mutational landscape and intra-host diversity of human papillomavirus type 16 long control region and E6 variants in cervical samples
- Tratamiento de las neoplasias intraepiteliales escamosas y glandulares del cuello uterino
- MicroRNA-Based Fingerprinting of Cervical Lesions and Cancer
- Association of cervical carcinogenesis risk with HPV16 E6 and E7 variants in the Taizhou area, China
- The polymorphism analysis and epitope predicted of Alphapapillomavirus 9 E6 in Sichuan, China
- Genetic diversity of E6, E7 and the long control region in human papillomavirus type 16 variants in Beijing, China
- Epidemiology and Molecular Biology of HPV Variants in Cervical Cancer: The State of the Art in Mexico
- Epidemiología y prevención primaria y secundaria del cáncer de cérvix
- Genetic Variability in the E6/E7 Region of Human Papillomavirus 16 in Women from Ecuador
- Impact of HPV-16 Lineages Infection in Response to Radio-Chemotherapy in Cervical Cancer
- Épidémiologie et prévention primo-secondaire des cancers du col de l’utérus
- Prise en charge des néoplasies intraépithéliales malpighiennes et glandulaires du col utérin
- Prélèvement cervico-utérin : cytologie, virologie, prélèvement urinaire et autoprélèvement
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