Serum ribonuclease in multiple myeloma.
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Summary
Evidence is presented to show that most patients with multiple myeloma have an increased level of serum RNase, assayed with the synthetic polymer, polycytidylate, and the results suggest that the enzyme level may be a useful indicator of response to chemotherapy with the alkylating agents cyclophosphamide and melphalan in multipleMyeloma.
- Type
- article
- Published
- 1971-04-01
- Cited by
- 39
- References
- 32
- OpenAlex
- https://openalex.org/W2040293303
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:45911144
Keywords
Medicine, Multiple myeloma, Cyclophosphamide, Melphalan, Enzyme
References
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- Cyclophosphamide therapy. Its use in leukemia, lymphoma and solid tumors.
- Changes in ribonuclease activities in P1798 lymphosarcoma after asparaginase treatment.
- Purine and pyrimidine excretion in normal and leukemic subjects.
- Investigation of Ribonuclease Isozymes by an Electrophoretic Ultra-Violet Method
- MULTIPLE MYELOMA. STUDIES OF MOUSE PLASMA CELL TUMOR AND HUMAN MYELOMA RESPONSIVENESS TO CYCLOPHOSPHAMIDE (CYTOXAN).
- Existence of a third ribonuclease in rat-liver particulates.
- Pseudouridine metabolism. I. Isolation and the effect of diet on urinary excretion.
Cited by
- Mammalian nucleolytic enzymes.
- Serum ribonuclease activity in the diagnosis of pancreatic disease
- Time-dependent changes of plasma ribonuclease activity in female Wistar rats under combination therapy of ovarian carcinoma
- Assessment of the clinical usefulness of serum ribonuclease assays: An indicator for the detection of pancreatic cancer
- Caracterització estructural de Ribonucleases humanes
- Properties of a human liver ribonuclease. Inhibition by polynucleotides and specificity for phosphodiester bond cleavage to yield purine nucleosides at the 5' termini.
- Hepatocellular carcinoma with silent and cirrhotic non‐alcoholic steatohepatitis, accompanying ectopic liver tissue attached to gallbladder
- The isolation, purification, and properties of a ribonuclease (Mr 18 000) from human uremic serum, and its relation to the human urinary ribonuclease (Mr 33 000). I. Isolation of the low molecular weight ribonuclease.
- Immunological assay of pancreatic ribonuclease in serum as an indicator of pancreatic cancer.
- Levels of serum ribonuclease as an indicator of renal insufficiency in patients with leukemia.
- Possible sites of origin of human plasma ribonucleases as evidenced by isolation and partial characterization of ribonucleases from several human tissues.
- The isolation, purification, and properties of a ribonuclease from normal human urine.
- An assessment of the clinical usefulness of plasma ribonuclease assays.
- Inducers and induction of interferons
- Purification, characterization and development of radioimmunoassay of human liver ribonuclease.
- Nuclease detection in SDS-polyacrylamide gel electrophoresis.
- Plasma ribonuclease. A marker for the detection of ovarian cancer
- A method for the determination of alkaline ribonuclease (EC 3.1.4.22) activity in human serum.
- Poly (C) avid ribonuclease estimation in patients with solid tumors: A critical evaluation
- Radioimmunoassays for two types of human urinary ribonucleases: differential determination of ribonucleases in human serum.
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