Predictors of sustained virological response to a 48-week course of pegylated interferon alfa-2a and ribavirin in patients infected with hepatitis C virus genotype 4
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Summary
Almost half of HCV-4 patients who complete the course of combination therapy achieve an SVR, especially if they are young, treatment naivve and have lower AST levels, according to a multivariate regression analysis.
- Type
- article
- Published
- 2009-01-01
- Cited by
- 58
- References
- 60
- Access
- Open access
- OpenAlex
- https://openalex.org/W2039562476
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1779872
Keywords
Medicine, Ribavirin, Family medicine, Research centre, University hospital
References
- Early viral kinetics and treatment outcome in combination of high‐dose interferon induction vs. pegylated interferon plus ribavirin for naïve patients infected with hepatitis C virus of genotype 1b and high viral load
- Regression of Fibrosis in Chronic Hepatitis C After Therapy with Interferon and Ribavirin
- Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: impact of bilharziasis and fibrosis stage.
- Regression of Hepatic Fibrosis in Hepatitis C with Long-Term Interferon Treatment
- Hepatitis C virus genotypes in Saudi Arabia.
- Combination treatment of interferon alpha-2b and ribavirin in comparison to interferon monotherapy in treatment of chronic hepatitis C genotype 4 patients.
- Chronic hepatitis C. Genotypes and response to anti-viral therapy among Saudi patients.
- Correlation of serum aminotransferases with HCV RNA levels and histological findings in patients with chronic hepatitis C: the role of serum aspartate transaminase in the evaluation of disease progression
- Pegylated interferon alpha‐2b plus ribavirin in patients with genotype 4 chronic hepatitis C: The role of rapid and early virologic response
- Serum alpha-fetoprotein levels in patients with advanced hepatitis C: results from the HALT-C Trial.
- Sustained virological response to interferon‐α is associated with improved outcome in HCV‐related cirrhosis: A retrospective study
- Optimized virologic response in hepatitis C virus genotype 4 with peginterferon-alpha2a and ribavirin.
- Serum aspartate but not alanine aminotransferase levels help to predict the histological features of chronic hepatitis c viral infections in adults
- Treatment of chronic hepatitis C genotype IV with interferon–ribavirin combination in Saudi Arabia: a multicentre study
- Infection with Hepatitis C Virus Genotype 4 Is Associated with a Poor Response to Interferon-α
- Peginterferon α‐2b plus ribavirin compared with interferon α‐2b plus ribavirin for initial treatment of chronic hepatitis C in Saudi patients commonly infected with genotype 4
- IP‐10 predicts viral response and therapeutic outcome in difficult‐to‐treat patients with HCV genotype 1 infection
- Peginterferon Alfa-2b Plus Ribavirin for the Treatment of Chronic Hepatitis C Genotype 4
- Hepatitis C genotypes and subtypes in Saudi Arabia
- Distinct patterns of stimulus‐inducible chemokine mRNA accumulation in human fetal astrocytes and microglia
Cited by
- Treatment failure in chronic hepatitis C: Predictors other than viral kinetics
- Assessment of interleukin 28B genotype as a predictor of response to combined therapy with pegylated interferon plus ribavirin in HCV infected Egyptian patients.
- Relation of ALT and AST levels to the histopathological changes in liver biopsies of patients with chronic hepatitis C genotype 4.
- Facteurs prédictifs de réponse au traitement de l'hépatite C : étude rétrospective au CHU de Grenoble
- Evaluated outcomes in patients with Chronic Hepatitis C
- Sustained virological response and its treatment predictors in hepatitis C virus genotype 4 compared to genotypes 1, 2, and 3: a meta-analysis
- Role of IL-28B polymorphisms in virologic response to combined pegylated interferon and ribavirin therapy in genotype 4 chronic HCV infected patients with and without cirrhosis
- Real Response to Therapy in Chronic Hepatitis C Virus Patients: A Study From Iran
- Hepatitis C Genotype 4: Genotypic Diversity, Epidemiological Profile, and Clinical Relevance of Subtypes in Saudi Arabia
- Hepatic fibrosis and serum alpha-fetoprotein (AFP) as predictors of response to HCV treatment and factors associated with serum AFP normalisation after treatment.
- Is rs8099917 Polymorphism of IL-28B Gene a Good Predictor of Response to Therapy of HCV than rs12979860? An Egyptian Study
- The natural history and long‐term outcomes in patients with chronic hepatitis C genotype 4 after interferon‐based therapy
- The neglected hepatitis C virus genotypes 4, 5 and 6: an international consensus report
- Prediction of sustained virologic responses to combination therapy of pegylated interferon-α and ribavirin in patients with chronic hepatitis C infection
- Relationship of interferon-&ggr;-inducible protein-10 kDa with viral response in patients with various heterogeneities of hepatitis C virus genotype-4
- WITHDRAWN: Low dose ribavirin for treatment of HCV infected thalassemia major patients: New indications for combination therapy.
- The Impact of Interleukin 28b Gene Polymorphism on the Virological Response to Combined Pegylated Interferon and Ribavirin Therapy in Chronic HCV Genotype 4 Infected Egyptian Patients Using Data Mining Analysis
- Predicting the Outcomes of Combination Therapy in Patients With Chronic Hepatitis C Using Artificial Neural Network
- Non-Invasive Prediction of Hepatic Fibrosis in Patients With Chronic HCV Based on the Routine Pre-Treatment Workup
- Conventional Interferon Therapy Response among Chronic HCV Patients in Khyber Pakhtunkhwa
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