The hypothalamic–pituitary–adrenal–leptin axis and metabolic health: a systems approach to resilience, robustness and control
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Summary
A dynamic systems approach revealed that lower central inhibitory cortisol feedback signalling was significantly associated with greater metabolic risk, and leptin–cortisol antagonism may reflect a ‘neuroendocrine starvation’ response.
- Type
- article
- Published
- 2014-10-06
- Cited by
- 51
- References
- 72
- Access
- Open access
- OpenAlex
- https://openalex.org/W2038209586
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4842933
Keywords
Leptin, Robustness (evolution), Computer science, Hypothalamic–pituitary–adrenal axis, Bioinformatics
References
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- Leptin and the CNS Control of Glucose Metabolism
- Out-patient screening for Cushing's syndrome: the sensitivity of the combination of circadian rhythm and overnight dexamethasone suppression salivary cortisol tests.
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- Cortisol, obesity and the metabolic syndrome: A cross-sectional study of obese subjects and review of the literature
- Inhibition of cortisol secretion by dexamethasone in relation to body fat distribution: a dose-response study.
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- Long-term prospective and controlled studies demonstrate adipose tissue hypercellularity and relative leptin deficiency in the postobese state.
- Linking disease symptoms and subtypes with personalized systems-based phenotypes: A proof of concept study
- Cortisol secretion in relation to body fat distribution in obese premenopausal women.
- Reduction in Allostatic Load in Older Adults Is Associated With Lower All-Cause Mortality Risk: MacArthur Studies of Successful Aging
- Repeated Stress Impairs Endocannabinoid Signaling in the Paraventricular Nucleus of the Hypothalamus
- Glucocorticoids and neuroendocrine function
Cited by
- Circadian Clocks as Modulators of Metabolic Comorbidity in Psychiatric Disorders
- The role of leptin in regulating bone metabolism
- The tapestry of resilience: an emerging picture
- Hypothalamic-pituitary-adrenal axis dysregulation and cortisol activity in obesity: A systematic review.
- Visceral obesity and psychosocial stress: a generalised control theory model
- Circulating Angiogenic Cell Function is Inhibited by Cortisol in Vitro and Associated with Psychological Stress and Cortisol in Vivo
- Anxiolytic-like effects of leptin on fixed interval responding.
- Children's psychosocial stress and emotional eating: A role for leptin?
- Mechanism-based mathematical modelling of dynamics of the hypothalamic-pituitary-adrenal axis
- Robustesse, résilience : une brève synthèse des définitions au travers d'une analyse structurée de la littérature
- Neuroendocrine Drivers of Risk and Resilience: The Influence of Metabolism & Mitochondria
- A System Theoretic Investigation of Cortisol Dysregulation in Fibromyalgia Patients with Chronic Fatigue
- Nutritional Factors, Physical Health and Immigrant Status Are Associated with Anxiety Disorders among Middle-Aged and Older Adults: Findings from Baseline Data of The Canadian Longitudinal Study on Aging (CLSA)
- Leptin and psychiatric illnesses: does leptin play a role in antipsychotic-induced weight gain?
- Characterization of Cortisol Dysregulation in Fibromyalgia and Chronic Fatigue Syndromes: A State-Space Approach
- Prenatal stress and infants’ development: association with cortisol and leptin levels in cord blood and saliva
- The Impact of Photoperiod on the Leptin Sensitivity and Course of Inflammation in the Anterior Pituitary
- Depression and Cardiovascular Disease: The Viewpoint of Platelets
- Robustness, resilience: typology of definitions through a multidisciplinary structured analysis of the literature
- Direct and Indirect Effect of Honey as a Functional Food Against Metabolic Syndrome and Its Skeletal Complications
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