The minimal model of the hypothalamic–pituitary–adrenal axis
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Summary
It is demonstrated that un-physiological values of the parameters are needed in order to achieve local instability of the fixed point of the HPA axis, and small changes in physiologically relevant parameters cause the system to be globally stable using the analytical criteria.
- Type
- article
- Published
- 2011-10-01
- Cited by
- 76
- References
- 25
- OpenAlex
- https://openalex.org/W21107577
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12625398
Keywords
Art, Geography, Archaeology
References
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- Variability in the secretion of corticotropin-releasing hormone, adrenocorticotropic hormone and cortisol and understandability of the hypothalamic-pituitary-adrenal axis dynamics--a mathematical study based on clinical evidence.
- Plasma levels of corticotropin-releasing hormone in hypothalamic-pituitary-adrenal disorders and chronic renal failure.
- Mathematical modeling of the hypothalamic-pituitary-adrenal system activity.
- Pathophysiology of hypercortisolism in depression
- A feedback-controlled ensemble model of the stress-responsive hypothalamo-pituitary-adrenal axis
- Modeling robust oscillatory behavior of the hypothalamic-pituitary-adrenal axis
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- A mathematical model of the regulation system of the secretion of glucocorticoids
- Yoga, Part I: An Introduction
Cited by
- Achieving Remission in Gulf War Illness: A Simulation-Based Approach to Treatment Design
- Modeling the hypothalamus-pituitary-adrenal axis: A review and extension
- System identification of cortisol secretion: characterizing pulsatile dynamics
- A Mathematical Model of the Immune and Neuroendocrine Systems Mutual Regulation under the Technogenic Chemical Factors Impact
- Transcriptional implications of ultradian glucocorticoid secretion in homeostasis and in the acute stress response.
- Systems Biology of Complex Symptom Profiles: Capturing Interactivity across Behavior, Brain and Immune Regulation
- Quantifying Pituitary-Adrenal Dynamics and Deconvolution of Concurrent Cortisol and Adrenocorticotropic Hormone Data by Compressed Sensing
- A Minimal Physiologically Based Model of the HPA Axis under Influence of the Sleep-Wake Cycles
- A Role for Homeostatic Drive in the Perpetuation of Complex Chronic Illness: Gulf War Illness and Chronic Fatigue Syndrome
- Mathematical modeling of light-mediated HPA axis activity and downstream implications on the entrainment of peripheral clock genes.
- The hypothalamic–pituitary–adrenal–leptin axis and metabolic health: a systems approach to resilience, robustness and control
- Systems biology approach to understanding post-traumatic stress disorder.
- Modeling Cortisol Dynamics in the Neuro-endocrine Axis Distinguishes Normal, Depression, and Post-traumatic Stress Disorder (PTSD) in Humans
- Dynamics of the HPA axis and inflammatory cytokines: Insights from mathematical modeling
- Differentiation between genomic and non-genomic feedback controls yields an HPA axis model featuring Hypercortisolism as an irreversible bistable switch
- Patient-specific modeling of the neuroendocrine HPA-axis and its relation to depression: Ultradian and circadian oscillations.
- Deconvolution of Serum Cortisol Levels by Using Compressed Sensing
- Hypothalamic-pituitary-adrenal axis dysregulation and cortisol activity in obesity: A systematic review.
- Computationally Modeling Lipid Metabolism and Aging: A Mini-review
- Heart rate variability and rhythmic influences in human endotoxemia
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