The agonist effect of dihydropyridines on Ca channels
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Summary
Measurements of single channel and whole cell cardiac Ca currents after application of two DHP agonists BAY K 8644 and CGP 28 392 show an increase in the probability that a single Ca channel, having opened and closed, will subsequently re-open during membrane depolarization.
- Type
- article
- Published
- 1984-10-11
- Cited by
- 246
- References
- 14
- OpenAlex
- https://openalex.org/W2037993075
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4303568
Keywords
Chemistry, Inotrope, Biophysics, Depolarization, Contractility
References
- Electrical properties of individual cells isolated from adult rat ventricular myocardium.
- Similarity of unitary Ca2+ currents in three different species
- Studies of single calcium channel currents in rat clonal pituitary cells.
- Dihydropyridine BAY-K-8644 activates chromaffin cell calcium channels
- Early Outward Current in Rat Single Ventricular Cells
- Novel dihydropyridines with positive inotropic action through activation of Ca2+ channels
- Properties of single calcium channels in cardiac cell culture
- Calcium channels: direct identification with radioligand binding studies
- Pacemaker activity and mitosis in cultures of newborn rat heart ventricle cells.
- Ca2+ channel modulation by 8-bromocyclic AMP in cultured heart cells
- Sodium and calcium channels in bovine chromaffin cells
- Photoalteration of calcium channel blockade in the cardiac Purkinje fiber.
- Heart: excitation and contraction.
- Spontaneously active cells isolated from the sino-atrial and atrio-ventricular nodes of the rabbit heart.
Cited by
- Direct coupling of the somatostatin receptor to potassium channels by a G protein.
- Mitogens and oncogenes can block the induction of specific voltage-gated ion channels.
- Pharmacological properties of the chromaffin cell calcium channel.
- Neurotoxins That Act Selectively on Voltage‐Dependent Cardiac Calcium Channels
- Pharmacological modulation of voltage-dependent calcium channels in intact cells.
- Investigating the Calcium Signaling at Ribbon Synapses
- Characterization of the role of calcium and sodium channels in the stimulus secretion coupling of 5-hydroxytryptamine release from porcine enterochromaffin cells
- Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters
- Ion Channel Reconstitution
- Mechanical consequences of calcium channel modulation during volatile anesthetic-induced left ventricular systolic and diastolic dysfunction.
- Modulation of calcium channel currents in guinea‐pig single ventricular heart cells by the dihydropyridine Bay K 8644.
- Cellular and molecular characterization of Ca2+ currents in acutely isolated, adult rat neostriatal neurons
- Large depolarization induces long openings of voltage-dependent calcium channels in adrenal chromaffin cells
- CaV1.3 Channels Are Essential for Development and Presynaptic Activity of Cochlear Inner Hair Cells
- Postsynaptic spike firing reduces synaptic GABAA responses in hippocampal pyramidal cells
- Purification of a new dimeric protein from Cliona vastifica sponge, which specifically blocks a non-L-type calcium channel in mouse duodenal myocytes.
- Failure of Bay K 8644 to induce RhoA kinase‐dependent calcium sensitization in rabbit blood vessels
- Hemodynamic effects of a calcium channel promoter, BAY y 5959, are preserved after chronic administration in ischemic heart failure in conscious dogs.
- A dihydropyridine calcium channel blocker with phosphodiesterase inhibitory activity: effects on cultured vascular smooth muscle and cultured heart cells.
- Recovery of the slow action potential is hastened by the calcium slow channel agonist, Bay-K-8644.
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