Glutamate Receptor Ion Channels: Structure, Regulation, and Function
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Summary
This review discusses International Union of Basic and Clinical Pharmacology glutamate receptor nomenclature, structure, assembly, accessory subunits, interacting proteins, gene expression and translation, post-translational modifications, agonist and antagonist pharmacology, allosteric modulation, mechanisms of gating and permeation, roles in normal physiological function, as well as the potential therapeutic use of pharmacological agents acting at glutamate receptors.
- Type
- review
- Published
- 2010-09-01
- Cited by
- 3,482
- References
- 1,411
- Access
- Open access
- OpenAlex
- https://openalex.org/W2037852973
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8989597
Keywords
Glutamate receptor, Metabotropic glutamate receptor, Cell biology, Gating, Ion channel linked receptors
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Cited by
- Structure, function, and pharmacology of NMDA receptor channels.
- The Regulation of Dendritic Spine Plasticity by EphB and N-methyl-D-aspartate Receptors Through Spatial Control Over Cofilin Activity in Mature Hippocampal Neurons
- Glutamate receptor ion channels: where do all the calories go?
- NMDA receptor subunit composition controls synaptogenesis and synapse stabilization
- Altered Learning and Arc-Regulated Consolidation of Learning in Striatum by Methamphetamine-Induced Neurotoxicity
- K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study
- Potentiation of NMDA Receptor-Dependent Cell Responses by Extracellular High Mobility Group Box 1 Protein
- Structural Mechanism of N-Methyl-D-Aspartate Receptor Type 1 Partial Agonism
- Protease-activated receptor-1 modulates hippocampal memory formation and synaptic plasticity
- Target- and Mechanism-Based Therapeutics for Neurodegenerative Diseases: Strength in Numbers
- Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures
- Auxiliary proteins promote modal gating of AMPA- and kainate-type glutamate receptors
- Modulatory mechanisms and multiple functions of somatodendritic A-type K+ channel auxiliary subunits
- Trafficking of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor (AMPA) Receptor Subunit GluA2 from the Endoplasmic Reticulum Is Stimulated by a Complex Containing Ca2+/Calmodulin-activated Kinase II (CaMKII) and PICK1 Protein and by Release of Ca2+ from Internal Stores*
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- Senile Dementia from Neuroscientific and Islamic Perspectives
- A Structural Biology Perspective on NMDA Receptor Pharmacology and Function
- Electrophysiological properties of NG2+ cells: Matching physiological studies with gene expression profiles
- A Toolkit for Orthogonal and in vivo Optical Manipulation of Ionotropic Glutamate Receptors
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