Structural Mechanism of N-Methyl-D-Aspartate Receptor Type 1 Partial Agonism
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Summary
It is demonstrated that the partial agonist cannot exert firm GluN1-LBDclosure, especially if there is even a small force that disrupts the LBD closure, which suggests the importance of forces from the ion channel for the relationship between pharmacological response and the structure of the L BD of members of this receptor family.
- Type
- article
- Published
- 2012-10-15
- Cited by
- 19
- References
- 55
- Access
- Open access
- OpenAlex
- https://openalex.org/W23077649
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2738282
Keywords
Continuing education, Management, Medical education, Political science, Sociology
References
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- BODIL: a molecular modeling environment for structure-function analysis and drug design
- A comparative analysis of the role of water in the binding pockets of ionotropic glutamate receptors.
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- Conformational Changes at the Agonist Binding Domain of the N-Methyl-d-Aspartic Acid Receptor*
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- Full and Partial Agonism of Ionotropic Glutamate Receptors Indicated by Molecular Dynamics Simulations
Cited by
- Asynchronous Movements Prior to Pore Opening in NMDA Receptors
- MMGBSA As a Tool To Understand the Binding Affinities of Filamin-Peptide Interactions
- Molecular mechanism of T-cell protein tyrosine phosphatase (TCPTP) activation by mitoxantrone.
- Reduced curvature of ligand-binding domain free energy surface underlies partial agonism at NMDA receptors
- Mechanism-Based Mathematical Model for Gating of Ionotropic Glutamate Receptors
- Inhibitory effects and oxidation of 6-methylcoumarin, 7-methylcoumarin and 7-formylcoumarin via human CYP2A6 and its mouse and pig orthologous enzymes
- Conformational transitions in the glycine-bound GluN1 NMDA receptor LBD via single-molecule FRET.
- Structure and gating of tetrameric glutamate receptors
- Structural Determinants of Agonist Efficacy at the Glutamate Binding Site of N-Methyl-d-Aspartate Receptors
- Case-specific performance of MM-PBSA, MM-GBSA, and SIE in virtual screening.
- Effect of ligand-binding on protein function
- Selective effect of cell membrane on synaptic neurotransmission
- Role of the Ion Channel Extracellular Collar in AMPA Receptor Gating
- A DFT approach to discriminate the antagonist and partial agonist activity of ligands binding to the NMDA receptor
- The GluN2B-Glu413Gly NMDA receptor variant arising from a de novo GRIN2B mutation promotes ligand-unbinding and domain opening
- Unlocking the Reverse Targeting Mechanisms of Cannabidiol: Unveiling New Therapeutic Avenues.
- Table of Contents
- University Continuing Education Units' Commitment to Research: Program Development as Scholarly Work
- Value of anti-N-methyl D-aspartate receptor in children with encephalitis: a prospective observational study.
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