The Lps locus: Genetic regulation of host responses to bacterial lipopolysaccharide
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Summary
Toll-like receptor 4 (Tlr4), a transmembrane protein with a cytoplasmic domain that bears homology to the Interleukin-1 receptor, has been identified as the gene encoded by Lps.
- Type
- review
- Published
- 1999-12-01
- Cited by
- 54
- References
- 75
- OpenAlex
- https://openalex.org/W2037478127
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:30205015
Keywords
Biology, TLR4, Lipopolysaccharide, Genetics, Locus (genetics)
References
- Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14
- A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
- Resistance of macrophages from C3H/HeJ mice to the in vitro cytotoxic effects of endotoxin.
- The genetic mapping of a defective LPS response gene in C3H/HeJ mice.
- Genetic control of in vivo sensitivity to lipopolysaccharide: evidence for codominant inheritance.
- The physical separation of Lps and Ifa loci in BXH recombinant inbred mice.
- C57BL/10/CR mice: nonresponders to activation by the lipid a moiety of bacterial lipopolysaccharide.
- Characterization of a congenitally LPS-resistant, athymic mouse strain.
- High Susceptibility of Strain A Mice to Endotoxin and Endotoxin-Red Blood Cell Mixtures
- Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
- A family of lipopolysaccharide binding proteins involved in responses to gram-negative sepsis.
- Genetic control of responses to bacterial lipopolysaccharides in mice. II. A gene that influences a membrane component involved in the activation of bone marrow-derived lymphocytes by lipipolysaccharides.
- Induction of macrophage-mediated tumor cytotoxicity by a hamster monoclonal antibody with specificity for lipopolysaccharide receptor.
- The response of recombinant inbred strains of mice to bacterial lipopolysaccharides.
- Genetic control of B cell activation by bacterial lipopolysaccharide is mediated by multiple distinct genes or alleles.
- Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene.
- Endotoxin and IL-1 hyporesponsiveness in a patient with recurrent bacterial infections.
- Stimulation of macrophages and neutrophils by complexes of lipopolysaccharide and soluble CD14.
- Specific endotoxic lipopolysaccharide-binding proteins on murine splenocytes. I. Detection of lipopolysaccharide-binding sites on splenocytes and splenocyte subpopulations.
- Generation and characterization of hamster-mouse hybridomas secreting monoclonal antibodies with specificity for lipopolysaccharide receptor.
Cited by
- Characterisation of inflammation in the central nervous system induced by lipoteichoic acid from Staphylococcus aureus : role of glia in the mechanisms of neuronal cell death
- Expression of nitric oxide synthase isoforms in the mouse kidney: cellular localization and influence by lipopolysaccharide and Toll-like receptor 4
- Recreational exposure to freshwater cyanobacteria : epidemiology, dermal toxicity and biological activity of cyanobacterial lipopolysaccharides
- Inflammatory proteins in the CNS-relation to Alzheimers disease
- MCP-1 expression in endotoxin-induced uveitis.
- The Cytotoxic Effects of Morinda Citrifolia Extracts Through TLR4 in Human Breast Cancer Cells
- Dual Effects of p38 MAPK on TNF-Dependent Bronchoconstriction and TNF-Independent Neutrophil Recruitment in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome1
- Endotoxin and Kupffer Cell Activation in Alcoholic Liver Disease
- Cyanobacterial lipopolysaccharides and human health – a review
- Macrophage Biology and Pathobiology in the Evolution of Immune Responses: A Functional Analysis
- Variations in susceptibility to proteoglycan-induced arthritis and spondylitis among C3H substrains of mice: evidence of genetically acquired resistance to autoimmune disease.
- Commensal-associated molecular patterns induce selective toll-like receptor-trafficking from apical membrane to cytoplasmic compartments in polarized intestinal epithelium.
- Viruses and Toll-like receptors.
- In vivo measurement of nitric oxide production in porcine gut, liver and muscle during hyperdynamic endotoxaemia
- Effect of pro-inflammatory stimuli on tumor cell-mediated induction of endothelial cell adhesion molecules in vitro.
- Genetic polymorphisms in host response to meningococcal infection: the role of susceptibility and severity genes.
- Genetic susceptibility to infectious diseases.
- Nitric oxide production by endotoxin preparations in TLR4-deficient mice.
- Increased expression and internalization of the endotoxin coreceptor CD14 in enterocytes occur as an early event in the development of experimental necrotizing enterocolitis.
- Endotoxin-induced proteolytic reduction in hepatic growth hormone (GH) receptor: a novel mechanism for GH insensitivity.
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