Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors.
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Summary
Comparison of DNA from tumor tissue (or cell lines derived from tumors) with DNA from unaffected tissues reveals structural rearrangements as well as changes in DNA methylation of the foreign DNA.
- Type
- article
- Published
- 1984-06-01
- Cited by
- 478
- References
- 54
- Access
- Open access
- OpenAlex
- https://openalex.org/W2036042116
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22571367
Keywords
Biology, Carcinogenesis, Molecular biology, Gene, Genetically modified mouse
References
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- Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
- Chromatin structure of endogenous retroviral genes and activation by an inhibitor of DNA methylation
- Evidence for non-spliced SV40 RNA in undifferentiated murine teratocarcinoma stem cells
- Differential regulation of metallothionein-thymidine kinase fusion genes in transgenic mice and their offspring.
- Independent mechanisms involved in suppression of the Moloney leukemia virus genome during differentiation of murine teratocarcinoma cells.
- Cellular transforming genes.
- A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells
- Transforming activity of human tumor DNAs.
- The SV40 A gene product is required for the production of a 54,000 MW cellular tumor antigen.
- Translocations among antibody genes in human cancer.
- DNA tumor viruses
- Microinjection of cloned retroviral genomes into mouse zygotes: integration and expression in the animal
Cited by
- Mammalian gene transfer and gene expression.
- Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease
- Animal models of human disease. Pathology and molecular biology of spontaneous neoplasms occurring in transgenic mice carrying and expressing activated cellular oncogenes.
- Transgenic mice as future tools in risk assessment.
- Angiogenesis: models and modulators.
- Chemical carcinogenesis: from animal models to molecular models in one decade.
- Transgenic and gene disruption techniques in the study of neurocarcinogenesis
- Simian virus 40 small t antigen activates the carboxyl-terminal transforming p53-binding domain of large T antigen
- Telomerase activation: one step on the road to cancer?
- Manipulating the germline: its impact on the study of carcinogenesis.
- Introduction and regulation of cloned genes for agricultural livestock improvement.
- Serum IgG Antibodies from Pregnant Women Reacting to Mimotopes of Simian Virus 40 Large T Antigen, the Viral Oncoprotein
- Gene expression and genetic engineering in the lens. Friedenwald lecture.
- Gene transfer into mouse embryos.
- SV40 T antigen transgenic mice: cytotoxic T lymphocytes as a selective force in tumor progression.
- Transgenic mouse models and peptide producing endocrine tumours: morpho-functional aspects.
- Polycystic kidney disease in SBM transgenic mice: role of c-myc in disease induction and progression.
- The susceptibility of primordial germ cells to malignant transformation and isolation and characterization of members of a new gene family differentially expressed in invasive and non-invasive immortalized male germ cells
- Targeting DNA methyltransferase in cancer
- Overview of transgenic and gene knockout mice.
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