Distinct dendritic cell subsets differentially regulate the class of immune response in vivo.
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Summary
It is suggested that distinct DC subsets have strikingly different influences on the type of immune response generated in vivo and may thus be targets for pharmacological intervention.
- Type
- article
- Published
- 1999-02-02
- Cited by
- 1,184
- References
- 37
- Access
- Open access
- OpenAlex
- https://openalex.org/W2035572849
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33761350
Keywords
Cytokine, Immunology, Biology, Ovalbumin, Immune system
References
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- Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.
- Antigen-specific B cells preferentially induce CD4+ T cells to produce IL-4.
- Dendritic cells and the control of immunity
- High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10 [published erratum appears in J Exp Med 1996 Oct 1;184(4):following 1590]
- The expanding universe of T-cell subsets: Th1, Th2 and more.
- CD4 T Cell Cytokine Differentiation: The B Cell Activation Molecule, OX40 Ligand, Instructs CD4 T Cells to Express Interleukin 4 and Upregulates Expression of the Chemokine Receptor, Blr-1
- The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype
- Acquisition of lymphokine-producing phenotype by CD4+ T cells.
- Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo.
- Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo.
- Cytokines induce the development of functionally heterogeneous T helper cell subsets.
- Mouse thymus dendritic cells: kinetics of development and changes in surface markers during maturation
- Th1 and Th2 subsets: paradigms lost?
- A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand- induced apoptosis
- Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population
- Unequal Death in T Helper Cell (Th)1 and Th2 Effectors: Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis
- A Natural Immunological Adjuvant Enhances T Cell Clonal Expansion through a CD28-dependent, Interleukin (IL)-2–independent Mechanism
Cited by
- Dendritic cells: The driving force behind autoimmunity in rheumatoid arthritis?
- Immunization with DNA encoding an immunodominant peptide of insulin prevents diabetes in NOD mice.
- CD2 Facilitates Differentiation of CD4 Th Cells Without Affecting Th1/Th2 Polarization1
- Gene Expression Profiling in Immune Cells Using Microarray
- Dendritic cell precursor populations of mouse blood: identification of the murine homologues of human blood plasmacytoid pre-DC2 and CD11c+ DC1 precursors.
- Long-Term Maintenance of gp120-Specific Immune Responses by Genetic Vaccination with the HIV-1 Envelope Genes Linked to the Gene Encoding Flt-3 Ligand 1
- Differential production of inflammatory chemokines by murine dendritic cell subsets.
- Unpulsed dendritic cells induce broadly applicable anti-tumor immunity in mice
- Cytokines and inflammatory mediators in cystic fibrosis.
- Expression, purification, and functional characterisation of flagellin, a TLR5-ligand.
- Variegation of the Immune Response with Dendritic Cells and Pathogen Recognition Receptors1
- Combinational FLt3 ligand and granulocyte macrophage colony-stimulating factor treatment promotes enhanced tumor infiltration by dendritic cells and antitumor CD8(+) T-cell cross-priming but is ineffective as a therapy.
- Signal transduction in DC differentiation: winged messengers and Achilles' heel.
- Dendritic Cells are preferentially targeted among hematolymphocytes by Modified Vaccinia Virus Ankara and play a key role in the induction of virus-specific T cell responses in vivo
- Distinct functional capacities of mouse thymic and splenic dendritic cell populations
- Development of a Novel CD4+ TCR Transgenic Line That Reveals a Dominant Role for CD8+ Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria
- Differential Effects of the Cytokine Thymic Stromal Lymphopoietin on Human Dendritic Cell Subsets
- T lymphocyte responses are critical determinants in the pathogenesis and resistance to mycoplasma respiratory disease.
- Generierung dendritischer Zellen zur Tumorimmuntherapie: Differenzierung, Antigenbeladung und Reifung innerhalb von 48 Stunden
- Gene immunotherapy for non-small cell lung cancer.
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