Transmembrane helix predictions revisited
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Summary
Surprisingly, it was found that proteins with more than five helices were predicted at a significantly lower accuracy than proteins with five or fewer, suggesting that structurally unsolved multispanning membrane proteins will remain problematic for transmembrane helix prediction algorithms.
- Type
- article
- Published
- 2002-12-01
- Cited by
- 224
- References
- 123
- Access
- Open access
- OpenAlex
- https://openalex.org/W2034410027
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7286233
Keywords
Transmembrane domain, Membrane protein, Transmembrane protein, Helix (gastropod), Proteome
References
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- N-tail translocation in a eukaryotic polytopic membrane protein: synergy between neighboring transmembrane segments.
- A topological analysis of subunit alpha from Escherichia coli F1F0-ATP synthase predicts eight transmembrane segments.
- Transmembrane Topology Prediction Methods: A Re-assessment and Improvement by a Consensus Method Using a Dataset of Experimentally-Characterized Transmembrane Topologies
- Topology prediction for helical transmembrane proteins at 86% accuracy–Topology prediction at 86% accuracy
- A simple experimental model for hydrophobic interactions in proteins.
- Refining Neural Network Predictions for Helical Transmembrane Proteins by Dynamic Programming
- Central adenosine A(2A) receptors: an overview.
- Gene-fusion techniques for determining membrane-protein topology
- Local alignment statistics.
- Computer Intensive Methods in Statistics
- CoPreTHi: A Web Tool which Combines Transmembrane Protein Segment Prediction Methods
- Hydrophilicity of polar amino acid side-chains is markedly reduced by flanking peptide bonds.
- Therapeutic potential of anti-IgE antibodies.
- Topological and functional studies on HlyB of Escherichia coli
Cited by
- Modulation of cell function by small transmembrane proteins modeled on the bovine papillomavirus E5 protein
- Has the code for protein translocation been broken?
- Understandable learning machine system design for Transmembrane or Embedded Membrane segments prediction
- Topology Prediction of Membrane Proteins: Why, How and When?
- The vesicular glutamate transporter (VGLUT): Heterologous expression, proteoliposome, computational and mass spectral studies
- Mapping the human proteome using bioinformatic methods
- Dimérisation du domaine transmembranaire des récepteurs de la famille ErbB/HER : étude par simulations de dynamique moléculaire
- Analysis on the Amino Acid Distributions with Position in Transmembrane Proteins
- Prediction of structure, function, and spectroscopic properties of G-protein-coupled receptors : methods and applications.
- Prediction Of Membrane Proteins Using Machine Learning Approaches
- The Proteomics Protocols Handbook
- Prédiction de la localisation des protéines membranaires : méthodes méta-heuristiques pour la détermination du potentiel d'insertion des acides aminés
- Studies on the Conformation of Transmembrane Polypeptides in Membrane Proteins
- Evaluation of transmembrane helix predictions in 2014
- A novel transmembrane topology of presenilin based on reconciling experimental and computational evidence
- Transmembrane segments prediction with support vector machine based on high performance encoding schemes
- Prediction of transmembrane topology and signal peptide given a protein's amino acid sequence.
- Les peptides d'ancrage à l'interface membranaire : analyses structurales par RMN et dynamique moléculaire et développement d'une méthode de prédiction bioinformatique
- Linear discrimination of transmembrane from non-transmembrane segments in proteins using higher-order crossings
- waveTM: Wavelet-Based Transmembrane Segment Prediction
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