Les mécanismes d’action de la diacerhéine, premier inhibiteur de l’interleukine 1 dans l’arthrose

Keywords

Chondrocyte, Osteoarthritis, Chemistry, Cartilage, Cytokine

References

• Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy.Kristen M. Clements, Joanne S. Price, M.G. Chambers — 2003
• Peroxisome proliferator--activated receptor gamma activators inhibit interleukin-1beta-induced nitric oxide and matrix metalloproteinase 13 production in human chondrocytes.Hassan Fahmi, John A. Di Battista, Jean‐Pierre Pelletier — 2001
• Evaluation of the structure-modifying effects of diacerein in hip osteoarthritis: ECHODIAH, a three-year, placebo-controlled trial. Evaluation of the Chondromodulating Effect of Diacerein in OA of the Hip.M Dougados, Minh Nguyen, Laurent Berdah — 2001
• Anti-interleukin-1 effects of diacerein and rhein in human osteoarthritic synovial tissue and cartilage cultures.Michael Yaron, Idit Shirazi, I Yaron — 1999
• In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy.Jean‐Pierre Pelletier, John P. Caron, Christopher H. Evans — 1997
• Expression of a Truncated, Kinase-Defective TGF-β Type II Receptor in Mouse Skeletal Tissue Promotes Terminal Chondrocyte Differentiation and OsteoarthritisRosa Serra, Mahlon D. Johnson, Ellen Filvaroff — 1997
• Diacerhein and rhein reduce the ICE-induced IL-1beta and IL-18 activation in human osteoarthritic cartilage.Florina Moldovan, Jean‐Pierre Pelletier, F C Jolicoeur — 2000
• Inhibition of Endogenous TGF-β During Experimental Osteoarthritis Prevents Osteophyte Formation and Impairs Cartilage RepairAlwin Scharstuhl, Harrie L. Glansbeek, Henk M. van Beuningen — 2002
• In vitro effects of diacerhein and rhein on interleukin 1 and tumor necrosis factor-alpha systems in human osteoarthritic synovium and chondrocytes.Johanne Martel‐Pelletier, François Mineau, F C Jolicoeur — 1998

Cited by

• Symptomatic efficacy and safety of diacerein in the treatment of osteoarthritis: a meta-analysis of randomized placebo-controlled trials.Else Marie Bartels, Henning Bliddal, P.K. Schøndorff — 2010

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