Symptomatic efficacy and safety of diacerein in the treatment of osteoarthritis: a meta-analysis of randomized placebo-controlled trials.
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Summary
Diacerein may be an alternative therapy for OA for patients who cannot take paracetamol or non-steroidal anti-inflammatory drugs (NSAIDs) because of adverse effects or lack of benefit, however, it is associated with increased risk of diarrhoea, and the symptomatic benefit after 6 months remains unknown.
- Type
- review
- Published
- 2010-03-01
- Cited by
- 87
- References
- 63
- Access
- Open access
- OpenAlex
- https://openalex.org/W1993562654
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:206302312
Keywords
Medicine, Placebo, Meta-analysis, Adverse effect, Relative risk
References
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- Evaluation of efficacy and safety of diacerein in knee osteoarthritis in Chinese patients.
- Mechanisms of action of diacerein, the first inhibitor of interleukin-1 in osteoarthritis
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- How close are we to having structure-modifying drugs available?
- Diacerhein in the treatment of osteoarthritis of the hip.
- Efficacy and tolerance of Harpagophytum procumbens versus diacerhein in treatment of osteoarthritis.
- Evaluation of the structure-modifying effects of diacerein in hip osteoarthritis: ECHODIAH, a three-year, placebo-controlled trial. Evaluation of the Chondromodulating Effect of Diacerein in OA of the Hip.
- The interleukin-1 receptor in normal and osteoarthritic human articular chondrocytes. Identification as the type I receptor and analysis of binding kinetics and biologic function.
- Blood concentrations of the cytokines IL-1beta, IL-6, IL-10, TNF-alpha and IFN-gamma during experimentally induced swine dysentery
- Efficacy of topical non-steroidal anti-inflammatory drugs in the treatment of osteoarthritis: meta-analysis of randomised controlled trials
- Risk of cardiovascular events associated with selective COX-2 inhibitors.
- Les mécanismes d’action de la diacerhéine, premier inhibiteur de l’interleukine 1 dans l’arthrose
- Systematic reviews in health care: Assessing the quality of controlled clinical trials.
Cited by
- Cartilage repair and joint preservation: medical and surgical treatment options.
- Effects of diacerein on cartilage and subchondral bone in early stages of osteoarthritis in a rabbit model
- Immune Modulation to Improve Tissue Engineering Outcomes for Cartilage Repair in the Osteoarthritic Joint
- The efficacy of duloxetine, non-steroidal anti-inflammatory drugs, and opioids in osteoarthritis: a systematic literature review and meta-analysis
- Tratamiento del paciente con artrosis
- The efficacy of diacerein in hand osteoarthritis: a double-blind, randomized, placebo-controlled study.
- Rhein: a potential biological therapeutic drug for intervertebral disc degeneration.
- Is Phytalgic® a goldmine for osteoarthritis patients or is there something fishy about this nutraceutical? A summary of findings and risk-of-bias assessment
- New avenues for the pharmacological management of type 2 diabetes: an update.
- Non-surgical management of early knee osteoarthritis
- Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials.
- Comparative study of drug intervention in treatment of rural middle-aged and elderly people with knee osteoarthritis in Fengxian District, Shanghai
- Temporal expression and tissue distribution of interleukin-1β in two strains of guinea pigs with varying propensity for spontaneous knee osteoarthritis
- A Posteriori Comparison of Natural and Surgical Destabilization Models of Canine Osteoarthritis
- In vivo reduction or blockade of interleukin-1β in primary osteoarthritis influences expression of mediators implicated in pathogenesis
- Effect of Diacerein on Insulin Secretion and Metabolic Control in Drug-Naïve Patients With Type 2 Diabetes
- Chondroprotective agents: are we being too dogmatic?
- Supplementary methods in the nonsurgical treatment of osteoarthritis.
- Efficacy and safety of glucosamine, diacerein, and NSAIDs in osteoarthritis knee: a systematic review and network meta-analysis
- OARSI guidelines for the non-surgical management of knee osteoarthritis.
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