Programmed death-1+ T cells and regulatory T cells are enriched in tumor-involved lymph nodes and associated with aggressive features in papillary thyroid cancer.
Explore this paper's citation graph
Summary
Increased Treg and PD-1(+) T cell frequencies in LN may be indicative of aggressive recurrent PTC and further elevated in TILN from patients with recurrent disease.
- Type
- article
- Published
- 2012-03-30
- Cited by
- 121
- References
- 35
- Access
- Open access
- OpenAlex
- https://openalex.org/W2032838951
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:207084874
Keywords
Lymph, Papillary thyroid cancer, Thyroid cancer, Cancer research, Pathology
References
- CD4 T cells: fates, functions, and faults.
- Variations in lymphokine generation by individual lymph nodes draining human malignant tumors
- Activation-induced expression of human programmed death-1 gene in T-lymphocytes.
- Interleukin-17 promotes angiogenesis and tumor growth.
- Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates
- Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired.
- Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer.
- Increasing Incidence of Thyroid Cancer in the United States, 1973-2002
- Programmed death-1 upregulation is correlated with dysfunction of tumor-infiltrating CD8+ T lymphocytes in human non-small cell lung cancer
- Molecular signature of CD8+ T cell exhaustion during chronic viral infection.
- Tumor-infiltrating NY-ESO-1–specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer
- Enhanced in vivo growth and resistance to rejection of tumor cells expressing dominant negative IFN gamma receptors.
- High numbers of tumor-infiltrating FOXP3-positive regulatory T cells are associated with improved overall survival in follicular lymphoma.
- Human Prostate-Infiltrating CD8+ T Lymphocytes are Oligoclonal and PD-1+
- Prognosis of patients with papillary thyroid carcinoma having clinically apparent metastasis to the lateral compartment.
- Early T Cell Signalling Is Reversibly Altered in PD-1+ T Lymphocytes Infiltrating Human Tumors
- Accumulation of regulatory T cells in sentinel lymph nodes is a prognostic predictor in patients with node-negative breast cancer.
- CD45RA on human CD8 T cells is sensitive to the time elapsed since the last antigenic stimulation.
- Features of Responding T cells in Cancer and Chronic Infection
- Accumulation of Foxp3+ T Regulatory Cells in Draining Lymph Nodes Correlates with Disease Progression and Immune Suppression in Colorectal Cancer Patients
Cited by
- Optimizing therapy for radioactive iodine-refractory differentiated thyroid cancer: Current state of the art and future directions
- Novel Radiotracer for ImmunoPET Imaging of PD-1 Checkpoint Expression on Tumor Infiltrating Lymphocytes.
- FoxP3 Expression in Papillary Thyroid Carcinoma: A Possible Resistance Biomarker to Iodine 131 Treatment
- Tumor-Associated Inflammatory Cells in Thyroid Carcinomas.
- Tumor Infiltrating PD1-Positive Lymphocytes and the Expression of PD-L1 Predict Poor Prognosis of Soft Tissue Sarcomas
- Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway
- Hashimoto's thyroiditis and papillary thyroid cancer: are they immunologically linked?
- Emerging roles of regulatory T cells in tumour progression and metastasis
- Influence of human immune cells on cancer: studies at the University of Colorado
- Mast cells induce epithelial-to-mesenchymal transition and stem cell features in human thyroid cancer cells through an IL-8–Akt–Slug pathway
- Revisiting Immune-Based Therapies for Aggressive Follicular Cell–Derived Thyroid Cancers
- Inhibition of Foxp3 in cancer cells induces apoptosis of thyroid cancer cells.
- A New Strategy for the Surgical Management of RLN Infiltrated by Well-Differentiated Thyroid Carcinoma
- Immune Response in Thyroid Cancer: Widening the Boundaries
- Targeting Thyroid Cancer Microenvironment: Basic Research and Clinical Applications
- PD-1+Tim-3+ CD8+ T Lymphocytes Display Varied Degrees of Functional Exhaustion in Patients with Regionally Metastatic Differentiated Thyroid Cancer
- The role of the inflammatory microenvironment in thyroid carcinogenesis.
- Metastatic Mechanisms in Follicular Cell-Derived Thyroid Cancer
- Tumor-infiltrating PD1-Positive Lymphocytes and FoxP3-Positive Regulatory T Cells Predict Distant Metastatic Relapse and Survival of Clear Cell Renal Cell Carcinoma.
- Differentiated thyroid carcinomas may elude the immune system by B7H1 upregulation.
Related papers
- [Modern aspects influencing the management of patients with papillary thyroid cancer].
- Lessons from Mouse Models of Thyroid Cancer
- Trends in thyroid cancer incidence and mortality in the United States, 1974–2013
- Evaluation of the Relationship Between Papillary Thyroid Cancer and Radiation Exposure
- Thyroid Cancer Screening in South Korea Increases Detection of Papillary Cancers with No Impact on Other Subtypes or Thyroid Cancer Mortality
- Effects of Anti-Cancer Drug Sensitivity-Related Genetic Differences on Therapeutic Approaches in Refractory Papillary Thyroid Cancer
- Global variation in the pattern of differentiated thyroid cancer.
- Incidence and mortality trends of thyroid cancer from 1980 to 2016.
- Multifocal papillary thyroid cancer in children and adults. Lecture