Poly(ethylene glycol) on the liposome surface: on the mechanism of polymer-coated liposome longevity.
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Summary
Computer simulation was used to demonstrate that relatively a small number of liposome-grafted molecules of hydrophilic and flexible polymer can create a dense protective conformational cloud over theliposome surface preventing opsonizing protein molecules from contacting liposomes.
- Type
- article
- Published
- 1994-10-12
- Cited by
- 487
- References
- 20
- OpenAlex
- https://openalex.org/W2032369546
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25172276
Keywords
Liposome, Ethylene glycol, Polymer, Biophysics, Materials science
References
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Cited by
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- Liposomes:Formulation and characterisation as contrast agents and as vaccine delivery systems
- Hydration of polyethylene glycol-grafted liposomes.
- Accelerated blood clearance of PEGylated liposomes following preceding liposome injection: effects of lipid dose and PEG surface-density and chain length of the first-dose liposomes.
- Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes.
- Enzymosomes with surface-exposed superoxide dismutase: in vivo behaviour and therapeutic activity in a model of adjuvant arthritis.
- Micelle-like Nanoparticles as Carriers for DNA and siRNA
- Natural liposomes and synthetic polymeric structures for biomedical applications.
- Interaction of Polyethyleneglycol-Phospholipid Conjugates with Cholesterol-Phosphatidylcholine Mixtures: Sterically Stabilized Liposome Formulations
- Liposomes
- Amphiphilic poly-N-vinylpyrrolidones: synthesis, properties and liposome surface modification.
- siRNA-loaded cationic liposomes for cancer therapy: Development, characterization and efficacy evaluation
- Liposomes and other vesicular systems: structural characteristics, methods of preparation, and use in nanomedicine.
- POLYMER MICELLES FOR TUNABLE DRUG RELEASE AND ENHANCED ANTITUMOR EFFICACY
- STUDY AND CHARACTERIZATION OF DUAL-FUNCTION AFFINITY CHROMATOGRAPHIC ADSORBENTS HAVING SIZE EXCLUSION AND ADSORPTION PROPERTIES TO ISOLATE, PURIFY AND RECOVER SMALL BIOMOLECULES FROM COMPLEX BIOLOGICAL MIXTURES
- Engineering Cellular Hemoglobin-Based Oxygen Carriers For Use In Transfusion Medicine
- Long-Circulating Emulsions (Oil-in-Water) as Carriers for Lipophilic Drugs
- Long-circulating, pH-sensitive liposomes.
- Enhancing photodynamic therapy of refractory solid cancers : Combining second-generation photosensitizers with multi-targeted liposomal delivery
- Advances in Blood Substitutes
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