Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes.
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Summary
The findings suggest that the selective binding of IgM to the second injected PEGylated liposomes and the subsequent complement activation by IgM resulted in the accelerated clearance and enhanced hepatic uptake of the second injectable P EGylatedliposomes.
- Type
- article
- Published
- 2006-05-01
- Cited by
- 556
- References
- 37
- OpenAlex
- https://openalex.org/W16515818
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25518653
Keywords
Multiculturalism, Multicultural education, Pedagogy, Cultural pluralism, Sociology
References
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- Selective delivery of doxorubicin to patients with breast carcinoma metastases by stealth liposomes
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- Efficient clearance of poly(ethylene glycol)-modified immunoenzyme with anti-PEG monoclonal antibody for prodrug cancer therapy.
- Sterically stabilized liposomes: a hypothesis on the molecular origin of the extended circulation times.
- ROLE OF COMPLEMENT ACTIVATION IN HYPERSENSITIVITY REACTIONS TO DOXIL AND HYNIC PEG LIPOSOMES: EXPERIMENTAL AND CLINICAL STUDIES
- 'Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption.
- The effect of surface coverage and conformation of poly(ethylene oxide) (PEO) chains of poloxamer 407 on the biological fate of model colloidal drug carriers.
- Influence of surface hydrophilicity of liposomes on their interaction with plasma protein and clearance from the circulation: studies with poly(ethylene glycol)-coated vesicles.
- Proteins of rat serum: I. Establishing a reference two‐dimensional electrophoresis map by immunodetection and microbore high performance liquid chromatography‐electrospray mass spectrometry
- Effect of the physicochemical properties of initially injected liposomes on the clearance of subsequently injected PEGylated liposomes in mice.
- Poly(ethylene glycol) on the liposome surface: on the mechanism of polymer-coated liposome longevity.
- Complement activation-related pseudoallergy caused by liposomes, micellar carriers of intravenous drugs, and radiocontrast agents.
- Kinetic analysis of AUC-dependent saturable clearance of liposomes: Mathematical description of AUC dependency
Cited by
- Bioresponsive HES-PEI conjugates for controlled shielding and deshielding of pDNA polyplexes
- Repeated injection of PEGylated solid lipid nanoparticles induces accelerated blood clearance in mice and beagles
- Repeated injections of PEGylated liposomal topotecan induces accelerated blood clearance phenomenon in rats.
- Clinical Nanomedicine: A Solution to the Chemotherapy Conundrum in Pediatric Leukemia Therapy
- Patterned Polypeptoid Brushes.
- Strategies to test nuclear localization of non-viral gene delivery vectors in vitro and in vivo
- Drug Carriers: Not an Innocent Delivery Man
- Anti-PEG IgM and complement system are required for the association of second doses of PEGylated liposomes with splenic marginal zone B cells.
- Pharmacokinetic Properties of Single and Repeated Injection of Liposomal Platelet Substitute in a Rat Model of Red Blood Cell Transfusion-Induced Dilutional Thrombocytopenia.
- Autoantibodies to RuvBL1 and RuvBL2: A Novel Systemic Sclerosis–Related Antibody Associated With Diffuse Cutaneous and Skeletal Muscle Involvement
- The efficient apoptotic induction of paclitaxel-loaded poly(n-vinylpyrrolidone)-block-poly( ε -caprolactone) nanoparticles in the in vitro study of lung cancer cell lines
- Perspectives in vector development for systemic cancer gene therapy
- Anti-PEG immunity: emergence, characteristics, and unaddressed questions
- Physicochemical characterization of artificial nanoerythrosomes derived from erythrocyte ghost membranes.
- Polymeric micelles for solubilization and targeting of hydrophobic drugs
- Interaction kinetics of serum proteins with liposomes and their effect on phospholipase-induced liposomal drug release.
- Pharmacokinetic Optimization of Docetaxel Dosing
- PEGylation as a strategy for improving nanoparticle-based drug and gene delivery
- Enhanced Solubility and Targeted Delivery of Drugs using Cucurbit[n]uril-Type Compounds
- Design of liposomal formulations for cell targeting.
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