Cell signaling by receptor-tyrosine kinases
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Summary
Understanding of the complex signaling networks downstream from RTKs and how alterations in these networks are translated into cellular responses provides an important context for therapeutically countering the effects of pathogenic RTK mutations in cancer and other diseases.
- Type
- review
- Published
- 2000-10-13
- Cited by
- 4,490
- References
- 143
- Access
- Open access
- OpenAlex
- https://openalex.org/W2028415754
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22285813
Keywords
Biology, Receptor tyrosine kinase, Context (archaeology), Tyrosine kinase, Cell biology
References
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- Oncogenic kinase signalling
- Rap1 mediates sustained MAP kinase activation induced by nerve growth factor
- Evidence for epidermal growth factor (EGF)-induced intermolecular autophosphorylation of the EGF receptors in living cells
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- Protein tyrosine phosphatases in cancer: friends and foes!
- Genetic Factors for Ischemic and Hemorrhagic Stroke in Japanese Individuals
- Unraveling the biologic and clinical complexities of HER2.
- An update on the biology of cancer stem cells in breast cancer
- Molecular Mechanisms Underlying Effects of Epidermal Growth Factor Receptor Inhibition on Invasion, Proliferation, and Angiogenesis in Experimental Glioma
- A New Family of Receptor Tyrosine Kinases with a Venus Flytrap Binding Domain in Insects and Other Invertebrates Activated by Aminoacids
- Caenorhabditis elegans has a phosphoproteome atypical for metazoans that is enriched in developmental and sex determination proteins.
- Global phosphoproteomic effects of natural tyrosine kinase inhibitor, genistein, on signaling pathways
- Kainate-induced toxicity in the hippocampus: potential role of lithium.
- Mutational Profiling of Kinases in Human Tumours of Pancreatic Origin Identifies Candidate Cancer Genes in Ductal and Ampulla of Vater Carcinomas
- PI3Kinase signaling in glioblastoma
- Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor
- Redox regulation of ERK1/2 activation induced by sphingosine 1-phosphate in fibroblasts: involvement of NADPH oxidase and platelet-derived growth factor receptor.
- Regulation of nerve growth factor signaling by protein phosphatase 2A
- Quantum dot-based quantitative immunofluorescence detection and spectrum analysis of epidermal growth factor receptor in breast cancer tissue arrays
- EphA2 receptor activation by monomeric Ephrin-A1 on supported membranes.
- p38 Inhibition ameliorates skin and skull abnormalities in Fgfr2 Beare-Stevenson mice.
- Modification of tomato growth by expression of truncated ERECTA protein from Arabidopsis thaliana.
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