Assessment of the potential uses of liposomes for lymphoscintigraphy and lymphatic drug delivery. Failure of 99m-technetium marker to represent intact liposomes in lymph nodes.
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Summary
It is suggested that liposomes can be used for the delivery of drugs to diseased lymph nodes, and it would be worthwhile examining the possibilities of using alternative methods of labelling liposome with 99mTc rather than using the SnCl2 technique, or using other radionuclides as markers for gamma-scan imaging.
- Type
- article
- Published
- 1984-09-07
- Cited by
- 87
- References
- 28
- OpenAlex
- https://openalex.org/W2028068697
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24878495
Keywords
Liposome, In vivo, Lymph, Lymphatic system, Chemistry
References
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- POTENTIAL APPLICATIONS OF LIPOSOMES TO THERAPY *
- Potential applications of radionuclide-labelled liposomes in the detection of the lymphatic spread of cancer.
- Problems associated with stannous 99mTc-radiopharmaceuticals.
- Localisation of experimental staphylococcal abscesses by 99MTC-technetium-labelled liposomes.
- High colloidal uptake in axillary nodes with metastatic disease
- The influence of experimental conditions on the efficiency of labeling human serum albumin with 99mTc, using Sn(II) as the reductant.
- Inhibitory effect of cholesterol on the uptake of liposomes by liver and spleen.
- DISTRIBUTION OF RADIONUCLIDE-LABELLED LIPOSOMES DRAINING FROM INFLAMED TISSUE.
- Fate of cholesterol-rich liposomes after subcutaneous injection into rats.
- Effect of liposome encapsulation of a fluorescent dye on its uptake by the lymphatics of the rat.
- The effect of reticuloendothelial blockade on the blood clearance and tissue distribution of liposomes.
- Tissue distribution and tumour localization of 99m-technetium-labelled liposomes in cancer patients.
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- Impact of Molecular Weight on Lymphatic Drainage of a Biopolymer-Based Imaging Agent
- Interactions of Mast Cells with the Lymphatic System: Delivery of Peripheral Signals to Lymph Nodes by Mast Cell-Derived Particles
- Preparation of Biodegradable, Surface Engineered PLGA Nanospheres with Enhanced Lymphatic Drainage and Lymph Node Uptake
- Biothérapies par voie sous-cutanée : modalités d’absorption et implications cliniques
- Liposomes as vaccine carriers. Incorporation of soluble and particulate antigens in giant vesicles.
- Who Is At Risk for Developing Chronic Anal Fistula or Recurrent Anal Sepsis After Initial Perianal Abscess?
- The effect of microfluidization of protein-coated liposomes on protein distribution on the surface of generated small vesicles.
- Fc receptor‐mediated transcytosis of IgG‐coated liposomes across epithelial barriers
- The Use of Scintigraphic Imaging During Liposome Drug Development
- Liposomes containing blue dye for preoperative lymph node staining: Distribution and stability in dogs after endolymphatic injection
- Pharmacokinetics of methotrexate after intravenous and intramuscular injection of methotrexate‐bearing neutral liposomes to rats
- Mechanistic Determinants of Biotherapeutics Absorption Following SC Administration
- Lymph node localization of non-specific antibody-coated liposomes.
- Pharmacokinetics of methotrexate after intravenous and intramuscular injection of methotrexate-bearing negatively charged liposomes to rats
- The use of scintigraphic imaging as a tool in the development of liposome formulations.
- Lymphatic targeting of zidovudine using surface-engineered liposomes
- Diagnostic nanocarriers for sentinel lymph node imaging.
- Effect of liposome surface charge on the stability of technetium (99mTc) radiolabelled liposomes.
- Attachment of 99mTc to lipid vesicles containing the lipophilic chelate dipalmitoylphosphatidylethanolamine-DTTA.
- Differentiation in hepatic and splenic phagocytic activity during reticuloendothelial blockade with cholesterol-free and cholesterol-rich liposomes.
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