Oligomeric interactions of TGF‐β and BMP receptors
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Summary
This work addresses the generation of TGF‐β and BMP receptor homo‐ and hetero‐oligomers and its roles as a mechanism capable of fast regulation of signaling by these crucial cytokines.
- Type
- review
- Published
- 2012-07-04
- Cited by
- 75
- References
- 153
- Access
- Open access
- OpenAlex
- https://openalex.org/W2027844145
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:30965209
Keywords
Homomeric, Cell biology, Receptor, BMPR2, Bone morphogenetic protein
References
- Monomeric and dimeric GDF-5 show equal type I receptor binding and oligomerization capability and have the same biological activity
- Endocytosis of the Type III Transforming Growth Factor-β (TGF-β) Receptor through the Clathrin-independent/Lipid Raft Pathway Regulates TGF-β Signaling and Receptor Down-regulation*
- Crystal structure of activin receptor type IIB kinase domain from human at 2.0 Å resolution
- The TGF-β Family
- Reconstitution and transphosphorylation of TGF‐beta receptor complexes.
- Mechanism of activation of the TGF-β receptor
- TGFβ–SMAD signal transduction: molecular specificity and functional flexibility
- Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.
- TGF‐β signalling is mediated by two autonomously functioning TβRI:TβRII pairs
- Isolation and characterization of activin receptor from mouse embryonal carcinoma cells. Identification of its serine/threonine/tyrosine protein kinase activity.
- A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor
- Homomeric interactions between type II transforming growth factor-beta receptors.
- Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs
- Distinct roles of the intracellular domains of transforming growth factor-beta type I and type II receptors in signal transduction.
- TGF-β signalling from cell membrane to nucleus through SMAD proteins
- Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase.
- Crystal structure of the human TβR2 ectodomain–TGF-β3 complex
- Crystal structure of the BMP-2–BRIA ectodomain complex
- Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition.
- Stromal inactivation of BMPRII leads to colorectal epithelial overgrowth and polyp formation
Cited by
- Progress in Relevant Growth Factors Promoting the Growth of Hair Follicle
- Potential mechanisms and applications of statins on osteogenesis: Current modalities, conflicts and future directions.
- Signaling Pathways Involved in Osteogenesis and Their Application for Bone Regenerative Medicine
- Novel bone morphogenetic protein signaling through Smad2 and Smad3 to regulate cancer progression and development
- Visualization of BRI1 and BAK1(SERK3) Membrane Receptor Heterooligomers during Brassinosteroid Signaling1[W][OPEN]
- Src-mediated Post-translational Regulation of Endoglin Stability and Function Is Critical for Angiogenesis*
- Transforming growth factor-β superfamily, implications in development and differentiation of stem cells
- GDF15 regulates Kv2.1-mediated outward K+ current through the Akt/mTOR signalling pathway in rat cerebellar granule cells
- Fine-tuned Shuttles for Bone Morphogenetic Proteins
- Two novel disease-causing variants in BMPR1B are associated with brachydactyly type A1
- Meta-Analysis of Genetic Programs between Idiopathic Pulmonary Fibrosis and Sarcoidosis
- AcvR1-mediated BMP signaling in second heart field is required for arterial pole development: Implications for myocardial differentiation and regional identity
- TGF-β: An Important Mediator of Allergic Disease and a Molecule with Dual Activity in Cancer Development
- HIV related pulmonary arterial hypertension: epidemiology in Africa, physiopathology, and role of antiretroviral treatment
- VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling
- Bone Morphogenetic Protein‐2 Induces Donor‐Dependent Osteogenic and Adipogenic Differentiation in Human Adipose Stem Cells
- Endocytosis and trafficking of BMP receptors: Regulatory mechanisms for fine-tuning the signaling response in different cellular contexts.
- The insulin response integrates increased TGF-β signaling through Akt-induced enhancement of cell surface delivery of TGF-β receptors
- TβRIII independently binds type I and type II TGF-β receptors to inhibit TGF-β signaling
- Development and characterization of human monoclonal antibodies that neutralize multiple TGFβ isoforms
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