NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease
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Summary
The effects of subunit composition on NMDAR properties, synaptic plasticity and cellular mechanisms implicated in neuropsychiatric disorders are reviewed and could provide new therapeutic strategies against dysfunctions of glutamatergic transmission.
- Type
- review
- Published
- 2013-05-20
- Cited by
- 2,414
- References
- 211
- OpenAlex
- https://openalex.org/W2024380057
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5263137
Keywords
NMDA receptor, Neuroscience, Glutamatergic, Synaptic plasticity, Glutamate receptor
References
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- Obligatory role of NR2A for metaplasticity in visual cortex.
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- Both NR2A and NR2B subunits of the NMDA receptor are critical for long-term potentiation and long-term depression in the lateral amygdala of horizontal slices of adult mice.
- NMDA receptor subunit composition controls synaptogenesis and synapse stabilization
- In Vivo Evidence for NMDA Receptor-Mediated Excitotoxicity in a Murine Genetic Model of Huntington Disease
- Metaplastic Regulation of Long-Term Potentiation/Long-Term Depression Threshold by Activity-Dependent Changes of NR2A/NR2B Ratio
- Functional and pharmacological differences between recombinant N-methyl-D-aspartate receptors.
- NMDAR EPSC kinetics do not regulate the critical period for LTP at thalamocortical synapses
- The receptor subunits generating NMDA receptor mediated currents in oligodendrocytes
- GluN1 splice variant control of GluN1/GluN2D NMDA receptors
- Extrasynaptic and synaptic NMDA receptors form stable and uniform pools in rat hippocampal slices
- Dynamin-dependent NMDAR endocytosis during LTD and its dependence on synaptic state
- Maintenance of superior learning and memory function in NR2B transgenic mice during ageing
- Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A
- A Developmental Change in NMDA Receptor-Associated Proteins at Hippocampal Synapses
- High-Affinity Zinc Inhibition of NMDA NR1–NR2A Receptors
- NR2B‐ and NR2D‐containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones
- Exon 5 and spermine regulate deactivation of NMDA receptor subtypes.
- CaMKII binding to GluN2B is critical during memory consolidation
Cited by
- Glutamatergic pathways as a target for the treatment of dyskinesias in Parkinson's disease.
- Genetically encoding a light switch in an ionotropic glutamate receptor reveals subunit-specific interfaces
- Extrasynaptic glutamate release through cystine/glutamate antiporter contributes to ischemic damage.
- Transcription factor Sp4 regulates expression of Nervous Wreck 2 to control NMDAR1 levels and dendrite patterning
- A Structural Biology Perspective on NMDA Receptor Pharmacology and Function
- Adjunctive sarcosine plus benzoate improved cognitive function in chronic schizophrenia patients with constant clinical symptoms: A randomised, double-blind, placebo-controlled trial
- Inhibiting effects of rhynchophylline on zebrafish methamphetamine dependence are associated with amelioration of neurotransmitters content and down-regulation of TH and NR2B expression.
- Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus
- A Systematic Review of Pre-clinical Studies
- Neuroprotective effect of a novel Chinese herbal decoction on cultured neurons and cerebral ischemic rats
- Astrocytes gate Hebbian synaptic plasticity in the striatum
- Effect of magnesium supplementation on depression status in depressed patients with magnesium deficiency: A randomized, double-blind, placebo-controlled trial.
- Enhanced astrocytic D-serine underlies synaptic damage after traumatic brain injury
- Comparative Pharmacological Study of Common NMDA Receptor Open Channel Blockers Regarding Their Affinity and Functional Activity toward GluN2A and GluN2B NMDA Receptors
- Metaplasticity at the addicted tetrapartite synapse: A common denominator of drug induced adaptations and potential treatment target for addiction
- Long-term treadmill exercise upregulated hippocampal learning-related genes without improving cognitive behavior in social isolated rats.
- ENDOGENOUS ANALGESIA, DEPENDENCE, AND LATENT PAIN SENSITIZATION
- NMDA RECEPTORS IN THE DORSAL VAGAL COMPLEX OF NORMAL AND DIABETIC MICE
- Antidepressant Interactions of Ketamine and Glycogen Synthase Kinase-3 (GSK3) in Mice
- NMDA and AMPA receptors: development and status epilepticus.
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