High-Affinity Zinc Inhibition of NMDA NR1–NR2A Receptors
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Summary
It is observed that under control conditions, in zero nominal Zn2+ solutions, the addition of low concentrations of heavy metal chelators markedly potentiates the responses of NR1a–NR2A receptors, but not ofNR1a-NR2B receptors, which suggests that traces of a heavy metal contaminate standard solutions and tonically inhibit NR1 a–NR 2A receptors.
- Type
- article
- Published
- 1997-08-01
- Cited by
- 656
- References
- 63
- Access
- Open access
- OpenAlex
- https://openalex.org/W1656913045
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17338543
Keywords
Receptor, Chemistry, NMDA receptor, Protein subunit, Biophysics
References
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- Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor.
- An endogenous metal appears to regulate NMDA receptor mediated 45Ca influx and toxicity in cultured cerebellar granule cells.
Cited by
- Functional consequences of NR2 subunit composition in single recombinant N-methyl-D-aspartate receptors.
- Inhibitory Mechanism of Store-operated Ca2+ Channels by Zinc*
- NMDA receptors as targets of heavy metal interaction and toxicity
- Supralinear potentiation of NR1/NR3A excitatory glycine receptors by Zn2+ and NR1 antagonist
- The over-expression of TRPC6 channels in HEK-293 cells favours the intracellular accumulation of zinc.
- Copper Inhibits NMDA Receptor-Independent LTP and Modulates the Paired-Pulse Ratio after LTP in Mouse Hippocampal Slices
- Role of Zinc in the Regulation of Autophagy During Ethanol Exposure in Human Hepatoma Cells
- Genetically encoding a light switch in an ionotropic glutamate receptor reveals subunit-specific interfaces
- Modulation of extrasynaptic NMDA receptors by synaptic and tonic zinc
- Zinc and the zinc proteome.
- Acid-Sensing Ion Channels: Regulation And Physiologic Function
- AMPA and NMDA receptors expressed by differentiating Xenopus spinal neurons.
- Positions in the glun2c-containing nmdar regulate alcohol sensitivity and ion channel gating
- Regulation of protein phosphatases in oxidatively stressed neurons
- Extracellular Modulation of NMDA Receptors
- Is zinc the link between compromises of brain perfusion (excitotoxicity) and Alzheimer's disease?
- NMDA RECEPTORS IN THE DORSAL VAGAL COMPLEX OF NORMAL AND DIABETIC MICE
- A study of ion channels modulating synaptic transmission using a cerebellar Purkinje cell nerve-bouton preparation
- Functional role of kainate receptors in the rat entorhinal cortex.
- SYNTHETIC AROMATIC AGMATINE ANALOGS AS ALLOSTERIC MODULATORS OF THE N-METHYL-D-ASPARTATE (NMDA) RECEPTOR CHANNEL
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