Molecular mechanisms of caspase regulation during apoptosis
Explore this paper's citation graph
Summary
The present understanding of caspase regulation during apoptosis is described and biochemical and structural studies have led to important advances in understanding the underlying molecular mechanisms of cispase regulation.
- Type
- review
- Published
- 2004-11-01
- Cited by
- 2,008
- References
- 135
- OpenAlex
- https://openalex.org/W2024105041
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19498556
Keywords
Caspase, Effector, Apoptosis, Cell biology, Caspase 2
References
- Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35.
- Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization.
- HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins*
- Caspase activation: revisiting the induced proximity model.
- The Drosophila caspase DRONC cleaves following glutamate or aspartate and is regulated by DIAP1, HID, and GRIM.
- IAP proteins: blocking the road to death's door
- A structural view of mitochondria-mediated apoptosis
- An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9*
- Worms, Life, and Death (Nobel Lecture)
- Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway
- Apoptosis in the nervous system
- Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex
- Controlling the Caspases
- A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis
- Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding.
- NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP
- Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat
- A caspase-related protease regulates apoptosis in yeast.
- Mechanisms of caspase activation and inhibition during apoptosis.
- A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death.
Cited by
- Mast cell apoptosis and survival.
- Cytoplasmic Inclusions of TDP-43 in Neurodegenerative Diseases: A Potential Role for Caspases
- Discovery, regulation, and action of the major apoptotic nucleases DFF40/CAD and endonuclease G
- Structure of the apoptotic protease-activating factor 1 bound to ADP
- Molecular characterization of FK-506 binding protein 38 and its potential regulatory role on the anti-apoptotic protein Bcl-2.
- Possible role of Fas/Fas ligand‐mediated apoptosis in the pathogenesis of fixed drug eruption
- Production of reactive oxygen species in mitochondria of HeLa cells under oxidative stress.
- Apoptosis and Proliferation Markers in Diffusely Infiltrating Astrocytomas: Profiling of 17 Molecules
- Analyzing cell death events in cultured leukocytes.
- Caspase-3 status is a determinant of the differential responses to genistein between MDA-MB-231 and MCF-7 breast cancer cells.
- A Mitogen-Activated Protein Kinase Signals to Programmed Cell Death Induced by Self-Incompatibility in Papaver Pollen1[OA]
- Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.
- Suppressor of cytokine signaling-1 inhibits caspase activation and protects from cytokine-induced beta cell death
- NEW INSIGHTS INTO THE REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION DURING APOPTOSIS
- New Insights into the Apoptotic Process in Mollusks: Characterization of Caspase Genes in Mytilus galloprovincialis
- A novel TNFR1-triggered apoptosis pathway mediated by class IA PI3Ks in neutrophils.
- Proteolytic breakdown of cytoskeleton induces neurodegeneration during pathology of murine cerebral malaria.
- p53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2.
- Simultaneous modulation of COX‐2, p300, Akt, and Apaf‐1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells
- zVAD-fmk upregulates caspase-9 cleavage and activity in etoposide-induced cell death of mouse embryonic fibroblasts.
Related papers
- Caspase-2: controversial killer or checkpoint controller?
- Caspases, apoptosis and aging.
- Effector Caspases and Leukemia
- Targeted disruption of caspase genes in mice: What they tell us about the functions of individual caspases in apoptosis
- What are caspases 3 and 7 doing upstream of the mitochondria?
- Inhibition of caspase activity induces a switch from apoptosis to necrosis
- The role of caspases in apoptosis.
- Bcl-2–regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9
- The role of caspases as executioners of apoptosis.
- Comparative study of apoptosis induced by H(2)O(2) and NO: limitation of apoptosis induced by NO due to slower recovery of activity of NO-modified caspase.