Caspase activation: revisiting the induced proximity model.
Explore this paper's citation graph
Summary
The Induced Proximity hypothesis, originally proposed to explain the activation of initiate caspases, has recently been reinterpreted to be proximity-driven dimerization of initiator caspase, and consequently their activation.
- Type
- review
- Published
- 2004-06-25
- Cited by
- 376
- References
- 20
- Access
- Open access
- OpenAlex
- https://openalex.org/W197615574
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10129334
Keywords
Caspase, Effector, Biology, Cell biology, Enzyme activator
References
- Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization.
- A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis
- Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding.
- Mechanisms of caspase activation and inhibition during apoptosis.
- Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation.
- A unified model for apical caspase activation.
- Oligomerization and activation of caspase-9, induced by Apaf-1 CARD
- Caspase-9 Can Be Activated without Proteolytic Processing*
- The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity.
- Insights into the regulatory mechanism for caspase-8 activation.
- Caspases: enemies within.
- Dimer formation drives the activation of the cell death protease caspase 9
- Caspase-9 and APAF-1 form an active holoenzyme.
- Synthetic activation of caspases: artificial death switches.
- An Induced Proximity Model for Caspase-8 Activation*
- Autoproteolytic activation of pro-caspases by oligomerization.
- Caspase activation: the induced-proximity model.
- Essential role of CED-4 oligomerization in CED-3 activation and apoptosis.
- Mechanism of XIAP-mediated inhibition of caspase-9.
- Structural basis for the activation of human procaspase-7
Cited by
- Clinging to life: cell to matrix adhesion and cell survival
- Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4.
- Contribution of the Caspase Gene Sequence Diversification to the Specifically Antiviral Defense in Invertebrate
- Regulation of the Apoptosome in Cancer
- Les rôles distincts des isoformes de myosine II non-musculaire dans des processus cellulaires impliquant le cytosquelette d'actine
- Identification of genes regulated during neuronal apoptosis using oligonucleotide microarrays
- Design, Synthesis and Biological Evaluation of Non-Peptidic Small Molecular SMAC Mimetics as Potent IAP Inhibitors.
- La modulation de l'apoptose dépendante du récepteur Fas : étude des évènements précoces de la voie de signalisation apoptotique dans un modèle de lymphocytes T humains
- Apoptosis and immunity: characterizing the cell death machinery in the yellow fever mosquito, Aedes aegypti
- Génération et amélioration de protéines chimériques solubles associant un TCRγδ et la molécule pro-apoptotique FasL
- Contribution des protéines issues du liquide synovial dans la protection et la survie des PMN humains : chimioprotection : étude comparative des mécanismes d’action impliqués par rapport au GM-CSF
- Proteomic and molecular characterisation of TRAIL-induced signalling complexes
- Glutamatergic nmda and ampa receptors functional regulation in streptozotocin induced diabetic rats: effect of vitamin d3 and curcumin supplementation
- Ligand binding and receptor network formation in the tumor necrosis factor superfamily.
- The Connections Between Neural Crest Development and Neuroblastoma
- Inherited and Somatic Genetic factors in Colorectal Cancer Development
- Regulation of mast cell survival and apoptosis
- Apoptosis: a way to maintain healthy individuals.
- 2‐Chlorodeoxyadenosine (cladribine) induces apoptosis in human monocyte‐derived dendritic cells
- In silico und in vitro Screening von Proteinliganden zur Apoptoseinduktion
Related papers
- Caspase-2: controversial killer or checkpoint controller?
- Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway
- Caspases and caspase inhibitors.
- Mechanisms of caspase activation.
- Molecular determinants involved in activation of caspase 7.
- An optimized activity-based probe for the study of caspase-6 activation
- Activation and Specificity of human Caspase-10
- Caspases in apoptotic death.
- Inducible Dimerization and Inducible Cleavage Reveal a Requirement for Both Processes in Caspase-8 Activation*