Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA.
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Summary
This work reports the identification, purification, and cDNA cloning of a novel MeCP called MeCP2, which unlike MeCP1, the new protein is able to bind to DNA that contains a single methyl-CpG pair.
- Type
- article
- Published
- 1992-06-12
- Cited by
- 1,398
- References
- 49
- OpenAlex
- https://openalex.org/W1975791071
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6825994
Keywords
Biology, Chromatin, DNA methylation, Heterochromatin, Molecular biology
References
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- Isolation and sequencing of cDNA clones encoding Drosophila chromosomal protein D1. A repeating motif in proteins which recognize at DNA.
- The A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure.
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- Alternative processing of mRNAs encoding mammalian chromosomal high-mobility-group proteins HMG-I and HMG-Y
- Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.
- Tissue-specific in vitro transcription from the mouse albumin promoter.
- Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs.
- 5-Methylcytosine localised in mammalian constitutive heterochromatin
- Chromatin structure of endogenous retroviral genes and activation by an inhibitor of DNA methylation
- Nucleotide sequence of mouse satellite DNA.
- De novo methylation, expression, and infectivity of retroviral genomes introduced into embryonal carcinoma cells.
- Estrogen induces a demethylation at the 5' end region of the chicken vitellogenin gene.
- Inhibition of herpes simplex thymidine kinase gene expression by DNA methylation is an indirect effect.
- The mechanism of C- and G-banding of chromosomes.
- Consensus sequence of mouse satellite dna indicates it is derived from tandem 116 basepair repeats
Cited by
- Establishment and maintenance of DNA methylation patterns in mammals.
- Identification and Characterization of Novel Sir3/MeCP2-Chromatin Interactions
- Rett syndrome and the MECP2 gene
- Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia
- Transcriptional Silencing of Retroviral Vectors.
- MECP2 mutation analysis in patients with mental retardation
- The human receptor tyrosine kinase Axl gene--promoter characterization and regulation of constitutive expression by Sp1, Sp3 and CpG methylation.
- A novel DNA-binding feature of MeCP2 contributes to Rett syndrome
- MeCP2 Repression of G9a in Regulation of Pain and Morphine Reward
- Epigenetic control of gene expression.
- Proteins That Read DNA Methylation.
- Activation, Regulation and Transcription of the Human and Murine Globin Loci.
- Delayed maturation of neuronal architecture and synaptogenesis in cerebral cortex of Mecp2-deficient mice.
- Regulation of maize Ac/Ds transposition by replication and DNA methylation
- Genetic studies of children with mental retardation
- Principal causes of hot spots for cytosine to thymine mutations at sites of cytosine methylation in growing cells. A model, its experimental support and implications.
- Proteínas de unión a DNA metilado y cáncer: familia MBD (Methyl-CpG Binding Domain)
- The epigenetic breakdown of cancer cells: from DNA methylation to histone modifications.
- Aberrant epigenetic landscape in intellectual disability.
- Anàlisi del gen MECP2 a la Síndrome de Rett, correlacions genotip-fenotip
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