Integration of telomere sequences with the draft human genome sequence
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Summary
This work uses specialized linear yeast artificial chromosome clones, each carrying a large telomere-terminal fragment of human DNA, to integrate most human telomeres with the working draft sequence, indicating that human subtelomeric regions are not simply buffers of nonfunctional ‘junk DNA’ next to the moleculartelomere, but are instead functional parts of the expressed genome.
- Type
- article
- Published
- 2001-02-15
- Cited by
- 95
- References
- 26
- Access
- Open access
- OpenAlex
- https://openalex.org/W2023435500
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4372915
Keywords
Telomere, Subtelomere, Biology, Genetics, Human genome
References
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- Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes.
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- Gene conversions mediating antigenic variation in Trypanosoma brucei can occur in variant surface glycoprotein expression sites lacking 70-base-pair repeat sequences
- The genome sequence of Drosophila melanogaster.
Cited by
- High-throughput single-molecule mapping links subtelomeric variants and long-range haplotypes with specific telomeres
- The DNA sequence and comparative analysis of human chromosome 5
- Una saga citogenética: El descubrimiento de los métodos de bandeo cromosómico. Significado y proyección bio-médica
- The end of all human DNA maps?
- Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling
- Primate segmental duplications: crucibles of evolution, diversity and disease
- Subtelomeric rearrangements in the mentally retarded: A comparison of detection methods
- High throughput screening of human subtelomeric DNA for copy number changes using multiplex amplifiable probe hybridisation (MAPH)
- A physical map of the human genome
- Identification of a novel retina-specific gene located in a subtelomeric region with polymorphic distribution among multiple human chromosomes.
- Sequence variants of the DRD4 gene in autism: Further evidence that rare DRD4 7R haplotypes are ADHD specific
- Genomic structure and evolution of the ancestral chromosome fusion site in 2q13-2q14.1 and paralogous regions on other human chromosomes.
- Unique Combination of 22q11 and 14qter Microdeletion Syndromes Detected Using Oligonucleotide Array-CGH
- Masked complex chromosome rearrangement in a child thought to have del(8qter) as the sole cytogenetic abnormality
- Telomere-surrounding regions are transcription-permissive 3D nuclear compartments in human cells.
- Dynamics and plasticity of chromosome ends: consequences in human pathologies
- Rapid detection of subtelomeric deletion/duplication by novel real‐time quantitative PCR using SYBR‐green dye
- A question of strategy.
- Telomeric position effect: from the yeast paradigm to human pathologies?
- Recent acceleration of human adaptive evolution
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