Active genes are tri-methylated at K4 of histone H3
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Summary
It is shown that the Saccharomyces cerevisiae Set1 protein can catalyse di- and tri-methylation of K4 and stimulate the activity of many genes, establishing the concept of methyl status as a determinant for gene activity and extending considerably the complexity of histone modifications.
- Type
- article
- Published
- 2002-09-26
- Cited by
- 2,259
- References
- 49
- OpenAlex
- https://openalex.org/W2022936129
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4356260
Keywords
Euchromatin, Methylation, EZH2, Histone H3, Histone
References
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Cited by
- Epigenetics of Stress Adaptation in Arabidopsis: the Case of Histone Modifications
- Chromatin higher order structure: opening up chromatin for transcription.
- Coordinated Changes in DNA Methylation and Histone Modifications Regulate Silencing/Derepression of Luteinizing Hormone Receptor Gene Transcription
- Eaf3 chromodomain interaction with methylated H3-K36 links histone deacetylation to Pol II elongation.
- Leaving a mark: the many footprints of the elongating RNA polymerase II.
- How to build a centromere: from centromeric and pericentromeric chromatin to kinetochore assembly.
- Spezies-spezifische und Zelltyp-spezifische Regulation von Toll-like Rezeptoren
- Nucleolin Regulates Gene Expression in CD34-positive Hematopoietic Cells*
- Subnuclear localization and mobility are key indicators of PAX3 dysfunction in Waardenburg syndrome.
- CHD8 Is an ATP-Dependent Chromatin Remodeling Factor That Regulates β-Catenin Target Genes
- Structural insight into the recognition of the H3K4me3 mark by the TFIID subunit TAF3.
- Differential remodeling of mono‐ and trimethylated H3K27 during porcine embryo development
- A Region of the Nucleosome Required for Multiple Types of Transcriptional Silencing in Saccharomyces cerevisiae
- Two Distinct Repressive Mechanisms for Histone 3 Lysine 4 Methylation through Promoting 3′-End Antisense Transcription
- Gadd45 proteins: key players of repair-mediated DNA demethylation.
- Specific promoter deacetylation of histone H3 is conserved across mouse models of Huntington's disease in the absence of bulk changes.
- Acidic domains differentially read histone H3 lysine 4 methylation status and are widely present in chromatin-associated proteins
- Separation of Methylated Histone Peptides via Host-Assisted Capillary Electrophoresis.
- Tackling malignant melanoma epigenetically: histone lysine methylation
- The Saccharomyces cerevisiae Paf1 transcription elongation complex is connected to chromatin modification through the multifunctional Rtf1 subunit and the inositol polyphosphate signaling pathway
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