Chromosomal translocations are associated with poor prognosis in chronic lymphocytic leukemia.
Explore this paper's citation graph
Summary
A new subgroup of patients with CLL defined by chromosomal trans-locations and poor prognosis is identified, and complex karyotype, CD38 expression, and 17p deletions-translocation proved to be the prognostic marker with the highest impact for an unfavorable clinical outcome.
- Type
- article
- Published
- 2006-01-15
- Cited by
- 278
- References
- 39
- Access
- Open access
- OpenAlex
- https://openalex.org/W2021964934
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16315219
Keywords
Chromosomal translocation, Chronic lymphocytic leukemia, Internal medicine, CD38, Oncology
References
- ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia.
- Immunostimulatory CpG-oligonucleotides induce functional high affinity IL-2 receptors on B-CLL cells: costimulation with IL-2 results in a highly immunogenic phenotype.
- National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment.
- CD40-activated B-cell chronic lymphocytic leukemia cells for tumor immunotherapy: stimulation of allogeneic versus autologous T cells generates different types of effector cells.
- Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia.
- Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.
- Chromosome aberrations in B-cell chronic lymphocytic leukemia. Pathogenetic and clinical implications.
- Cutting Edge: Role of Toll-Like Receptor 9 in CpG DNA-Induced Activation of Human Cells1
- Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells.
- Differential rates of somatic hypermutation in V(H) genes among subsets of chronic lymphocytic leukemia defined by chromosomal abnormalities.
- A high-resolution allelotype of B-cell chronic lymphocytic leukemia (B-CLL).
- Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL.
- Persistent Epstein‐Barr virus infection associated with monosomy 7 or chromosome 3 abnormality in childhood myeloproliferative disorders
- Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities.
- Cytogenetic Findings and Survival in B-cell Chronic Lymphocytic Leukemia. Second IWCCLL Compilation of Data on 662 Patients.
- Role of chromosomal abnormalities in chronic lymphocytic leukemia.
- Patients with de novo acute myeloid leukaemia and complex karyotype aberrations show a poor prognosis despite intensive treatment: a study of 90 patients
- A possible correlation between the degree of karyotype aberrations and the rate of sister chromatid exchanges in lymphoma lines
- CD40L stimulation enhances the ability of conventional metaphase cytogenetics to detect chromosome aberrations in B‐cell chronic lymphocytic leukaemia cells
- Loss of genetic material is more common than gain in acute myeloid leukemia with complex aberrant karyotype: A detailed analysis of 125 cases using conventional chromosome analysis and fluorescence in situ hybridization including 24‐color FISH
Cited by
- Integrated genomic profiling of chronic lymphocytic leukemia identifies subtypes of deletion 13q14.
- Whole-genome scanning by array comparative genomic hybridization as a clinical tool for risk assessment in chronic lymphocytic leukemia.
- Richter transformation in 16 of 149 Chinese patients with chronic lymphocytic leukemia
- CpG Oligonucleotide and Interleukin 2 stimulation enables higher cytogenetic abnormality detection rates than 12-o-tetradecanolyphorbol-13-acetate in Asian patients with B-cell chronic lymphocytic leukemia (B-CLL)
- The parallel application of karyotype interphase and metaphase FISH after DSP-30/IL-2 stimulation is necessary for the investigation of chronic lymphocytic leukemia
- What is the optimal management of older CLL patients?
- Acquired genomic copy number aberrations in CLL.
- Cytogenetic methods in chronic lymphocytic leukemia.
- Molecular biomarkers in chronic lymphocytic leukemia.
- Molecular and Genetic Evidence for Antigen Selection in the Pathogenesis of Chronic Lymphocytic Leukemia
- Telomere shortening associated with increased genomic complexity in chronic lymphocytic leukemia
- Stereotyped B Cell Receptors in Chronic Lymphocytic Leukaemia : Implications for Antigen Selection in Leukemogenesis
- Molecular cytogenetic lesions in chronic lymphocytic leukemia
- Genomic variation by whole-genome SNP mapping arrays predicts time-to-event outcome in patients with chronic lymphocytic leukemia: a comparison of CLL and HapMap genotypes.
- Structural alterations in chronic lymphocytic leukaemia. Cytogenetic and FISH analysis
- A new genetic abnormality leading to TP53 gene deletion in chronic lymphocytic leukaemia
- Translocations involving 13q14 without associated deletion in chronic lymphoid leukaemia target DLEU2
- Specific chromosomal IG translocations have different prognoses in chronic lymphocytic leukemia.
- The role of prognostic factors in assessing ‘high-risk’ subgroups of patients with chronic lymphocytic leukemia
- ALTA PROPORCIÓN DE TRANSCRITOS BCR/ABL EN PACIENTES CON LEUCEMIA MIELOIDE CRÓNICA EN COLOMBIA
Related papers
- A case of t (11;22)(q23.3;q11.2) balanced translocation with unilateral complete cleft lip and palate
- Molecular cytogenetic analysis of Triticum aestivum-Leymus racemosus reciprocal chromosomal translocation T7DS. 5LrL/T5LrS·7DL
- [The presence of t(14;18) chromosome translocation in various types of diseases].
- The Philadelphia (Ph) chromosome in leukemia. II. Variant Ph translocations in acute lymphoblastic leukemia.
- Translocation and trisomic Down's syndrome in a family with a familial D-G translocation.
- CD38 on B-cell chronic lymphocytic leukemia cells has higher expression in lymph nodes than in peripheral blood or bone marrow.
- CD38 expression does not change in B-cell chronic lymphocytic leukemia.
- Carbonyl group serum levels are associated with CD38 expression in patients with B chronic lymphocytic leukemia.