The JAK2-Akt-glycogen synthase kinase-3β signaling pathway is involved in toll-like receptor 2-induced monocyte chemoattractant protein-1 regulation
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Summary
Results suggest that a MyD 88-independent pathway exists in TLR2 signaling; the JAK2-Akt-GSK3β pathway is a novel MyD88- independent pathway for MCP-1 induction.
- Type
- article
- Published
- 2012-01-03
- Cited by
- 12
- References
- 37
- Access
- Open access
- OpenAlex
- https://openalex.org/W2021927651
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1650373
Keywords
Protein kinase B, TLR2, GSK-3, Signal transduction, Cell biology
References
- Protein kinase D1 is essential for MyD88-dependent TLR signaling pathway
- Chlamydia pneumoniae-Induced Foam Cell Formation Requires MyD88 Dependent and Independent Signaling and is Reciprocally Modulated by LXR Activation
- The specific role of chemokines in atherosclerosis
- Modulation of atherosclerosis in mice by Toll-like receptor 2.
- Pathogen recognition and innate immunity.
- Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer.
- High expression level of Toll-like receptor 2 on monocytes is an important risk factor for arteriosclerotic disease.
- Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
- Toll-like receptor–mediated cytokine production is differentially regulated by glycogen synthase kinase 3
- Mechanisms of Disease: Toll-like receptors in cardiovascular disease
- Cilostazol attenuates MCP‐1 and MMP‐9 expression in vivo in LPS‐administrated balloon‐injured rabbit aorta and in vitro in LPS‐treated monocytic THP‐1 cells
- Activation of PKC-epsilon and ERK1/2 participates in shear-induced endothelial MCP-1 expression that is repressed by nitric oxide.
- Lipopolysaccharide-induced c-Jun NH2-terminal Kinase Activation in Human Neutrophils
- Requirement of TLR2-mediated signaling for the induction of IL-15 gene expression in human monocytic cells by HSV-1.
- Toll-like receptor 9-stimulated monocyte chemoattractant protein-1 is mediated via JNK-cytosolic phospholipase A2-ROS signaling.
- Selective regulation of interleukin-10 production via Janus kinase pathway in murine conventional dendritic cells.
- Toll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipids.
- Therapeutic targeting of chemokine interactions in atherosclerosis
- IL-6/gp130/STAT3 signaling axis in cancer and the presence of in-frame gp130 somatic deletions in inflammatory hepatocellular tumors.
- Resveratrol inhibits foam cell formation via NADPH oxidase 1-mediated reactive oxygen species and monocyte chemotactic protein-1
Cited by
- Role of MCP-1 in Alcohol-induced Aggressiveness of Colorectal Cancer Cells
- Role of JAK2–STAT3 in TLR2‐mediated tissue factor expression
- Trichophyton rubrum conidia modulate the expression and transport of Toll-like receptor 2 in HaCaT cell.
- Dexmedetomidine protects against renal ischemia and reperfusion injury by inhibiting the JAK/STAT signaling activation
- Chlamydia pneumoniae Infection Promotes Vascular Smooth Muscle Cell Migration through a Toll-Like Receptor 2-Related Signaling Pathway
- GSK3 modulation in acute lung injury, myocarditis and polycystic kidney disease-related aneurysm
- Protective effects of sulfated polysaccharide from Enterobacter cloacae Z0206 against DSS-induced intestinal injury via DNA methylation.
- Molecular Mechanisms of Alcohol-Induced Colorectal Carcinogenesis
- Maresin 1 alleviates sevoflurane-induced neuroinflammation in neonatal rats via JAK2/STAT3/IL-6 pathways.
- Potential biomarkers and immune characteristics for polycythemia vera-related atherosclerosis using bulk RNA and single-cell RNA datasets: a combined comprehensive bioinformatics and machine learning analysis
- Chlamydia pneumoniae infection promotes vascular smooth muscle 1 cell migration through Toll-like receptor 2-related signaling 2 pathway 3 4
- TFEB degradation is regulated by an IKK/β-TrCP2 phosphorylation-ubiquitination cascade
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